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dc.contributor.authorJabaudon, D.
dc.contributor.authorJ. Shnider, S.
dc.contributor.authorJ. Tischfield, D.
dc.contributor.authorJ. Galazo, M.
dc.contributor.authorMacklis, Jeffrey Daniel
dc.date.accessioned2017-07-14T18:58:45Z
dc.date.issued2011
dc.identifier.citationJabaudon, D., S. J. Shnider, D. J. Tischfield, M. J. Galazo, and J. D. Macklis. 2011. “RORβ  Induces Barrel-Like Neuronal Clusters in the Developing Neocortex.” Cerebral Cortex 22 (5) (July 28): 996–1006. doi:10.1093/cercor/bhr182.en_US
dc.identifier.issn1047-3211en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33445960
dc.description.abstractNeurons in layer IV of the rodent whisker somatosensory cortex are tangentially organized in periodic clusters called barrels, each of which is innervated by thalamocortical axons transmitting sensory information from a single principal whisker, together forming a somatotopic map of the whisker pad. Proper thalamocortical innervation is critical for barrel formation during development, but the molecular mechanisms controlling layer IV neuron clustering are unknown. Here, we investigate the role in this mapping of the nuclear orphan receptor RORβ, which is expressed in neurons in layer IV during corticogenesis. We find that RORβ protein expression specifically increases in the whisker barrel cortex during barrel formation and that in vivo overexpression of RORβ is sufficient to induce periodic barrel-like clustering of cortical neurons. Remarkably, this clustering can be induced as early as E18, prior to innervation by thalamocortical afferents and whisker derived-input. At later developmental stages, these ectopic neuronal clusters are specifically innervated by thalamocortical axons, demonstrated by anterograde labeling from the thalamus and by expression of thalamocortical-specific synaptic markers. Together, these data indicate that RORβ expression levels control cytoarchitectural patterning of neocortical neurons during development, a critical process for the topographical mapping of whisker input onto the cortical surface.en_US
dc.description.sponsorshipStem Cell and Regenerative Biologyen_US
dc.language.isoen_USen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.isversionofdoi:10.1093/cercor/bhr182en_US
dash.licenseOAP
dc.subjectbarrel cortexen_US
dc.subjectcortical patterningen_US
dc.subjectcytoarchitectureen_US
dc.subjectRORben_US
dc.subjectthalamocortical innervationen_US
dc.titleRORβ  Induces Barrel-like Neuronal Clusters in the Developing Neocortexen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalCerebral Cortexen_US
dash.depositing.authorMacklis, Jeffrey Daniel
dc.date.available2017-07-14T18:58:45Z
dc.identifier.doi10.1093/cercor/bhr182*
dash.contributor.affiliatedMacklis, Jeffrey


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