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dc.contributor.authorShakhnovich, Boris E
dc.contributor.authorShakhnovich, Eugene Isaacovitch
dc.date.accessioned2017-07-18T18:34:25Z
dc.date.issued2008
dc.identifierQuick submit: 2017-05-15T21:51:14-0400
dc.identifier.citationShakhnovich, Boris E, and Eugene I Shakhnovich. 2008. “Improvisation in Evolution of Genes and Genomes: Whose Structure Is It Anyway?” Current Opinion in Structural Biology 18 (3) (June): 375–381. doi:10.1016/j.sbi.2008.02.007.en_US
dc.identifier.issn0959-440Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33464142
dc.description.abstractSignificant progress has been made in recent years in a variety of seemingly unrelated fields such as sequencing, protein structure prediction, and high-throughput transcriptomics and metabolomics. At the same time new microscopic models were developed that made it possible to analyze evolution of genes and genomes from first principles. The results from these efforts enable, for the first time, a comprehensive insight into the evolution of complex systems and organisms on all scales – from sequences to organisms and populations. Every newly sequenced genome uncovers new genes, families, and folds. Where do these new genes come from? How does gene duplication and subsequent divergence of sequence and structure affect the fitness of the organism? What role does regulation play in the evolution of proteins and folds? Emerging synergism between data and modeling provide first robust answers to these questions.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionof10.1016/j.sbi.2008.02.007en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533375/en_US
dash.licenseOAP
dc.titleImprovisation in evolution of genes and genomes: whose structure is it anyway?en_US
dc.typeJournal Articleen_US
dc.date.updated2017-05-16T01:50:32Z
dc.description.versionAccepted Manuscripten_US
dc.relation.journalCurrent Opinion in Structural Biologyen_US
dash.depositing.authorShakhnovich, Eugene Isaacovitch
dc.date.available2012
dc.date.available2017-07-18T18:34:25Z
dc.identifier.doi10.1016/j.sbi.2008.02.007*
dash.authorsorderedfalse
dash.contributor.affiliatedShakhnovich, Eugene


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