Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics
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CitationSerohijos, Adrian WR, and Eugene I Shakhnovich. 2014. “Merging Molecular Mechanism and Evolution: Theory and Computation at the Interface of Biophysics and Evolutionary Population Genetics.” Current Opinion in Structural Biology 26 (June): 84–91. doi:10.1016/j.sbi.2014.05.005.
AbstractThe variation among sequences and structures in nature is both determined by physical laws and by evolutionary history. However, these two factors are traditionally investigated by disciplines with different emphasis and philosophy—molecular biophysics on one hand and evolutionary population genetics in another. Here, we review recent theoretical and computational approaches that address the critical need to integrate these two disciplines. We first articulate the elements of these integrated approaches. Then, we survey their contribution to our mechanistic understanding of molecular evolution, the polymorphisms in coding region, the distribution of fitness effects (DFE) of mutations, the observed folding stability of proteins in nature, and the distribution of protein folds in genomes.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33464149
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