Nanowire nanoelectronics: Building interfaces with tissue and cells at the natural scale of biology

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Nanowire nanoelectronics: Building interfaces with tissue and cells at the natural scale of biology

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Title: Nanowire nanoelectronics: Building interfaces with tissue and cells at the natural scale of biology
Author: Cohen-Karni, Tzahi; Lieber, Charles M.

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Citation: Cohen-Karni, Tzahi, and Charles M. Lieber. 2013. “Nanowire Nanoelectronics: Building Interfaces with Tissue and Cells at the Natural Scale of Biology.” Pure and Applied Chemistry 85 (5) (January 11). doi:10.1351/pac-con-12-10-19.
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Abstract: The interface between nanoscale electronic devices and biological systems enables interactions at length scales natural to biology, and thus should maximize communication between these two diverse yet complementary systems. Moreover, nanostructures and nano - structured substrates show enhanced coupling to artificial membranes, cells, and tissue. Such nano–bio interfaces offer better sensitivity and spatial resolution as compared to conventional planar structures. In this work, we will report the electrical properties of silicon nanowires (SiNWs) interfaced with embryonic chicken hearts and cultured cardiomyocytes. We developed a scheme that allowed us to manipulate the nanoelectronic to tissue/cell interfaces while monitoring their electrical activity. In addition, by utilizing the bottom-up approach, we extended our work to the subcellular regime, and interfaced cells with the smallest reported device ever and thus exceeded the spatial and temporal resolution limits of other electrical recording techniques. The exceptional synthetic control and flexible assembly of nanowires (NWs) provides powerful tools for fundamental studies and applications in life science, and opens up the potential of merging active transistors with cells such that the distinction between nonliving and living systems is blurred.
Published Version: 10.1351/pac-con-12-10-19
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33464193
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