Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold
View/ Open
Author
Lemon, Christopher M.
Curtin, Peter N.
Somers, Rebecca C.
Greytak, Andrew B.
Lanning, Ryan M.
Bawendi, Moungi G.
Published Version
https://doi.org/10.1021/ic401587rMetadata
Show full item recordCitation
Lemon, Christopher M., Peter N. Curtin, Rebecca C. Somers, Andrew B. Greytak, Ryan M. Lanning, Rakesh K. Jain, Moungi G. Bawendi, and Daniel G. Nocera. 2014. “Metabolic Tumor Profiling with pH, Oxygen, and Glucose Chemosensors on a Quantum Dot Scaffold.” Inorganic Chemistry 53 (4) (February 17): 1900–1915. doi:10.1021/ic401587r.Abstract
Acidity, hypoxia and glucose levels characterize the tumor microenvironment rendering pH, pO2 and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These non-invasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.Other Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944830/Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:33464242
Collections
- FAS Scholarly Articles [18292]
Contact administrator regarding this item (to report mistakes or request changes)