Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies asin VivoTwo-Photon Oxygen Sensors
View/ Open
Author
Lemon, Christopher M.
Karnas, Elizabeth
Bruns, Oliver T.
Bawendi, Moungi G.
Published Version
https://doi.org/10.1021/jacs.5b04765Metadata
Show full item recordCitation
Lemon, Christopher M., Elizabeth Karnas, Xiaoxing Han, Oliver T. Bruns, Thomas J. Kempa, Dai Fukumura, Moungi G. Bawendi, Rakesh K. Jain, Dan G. Duda, and Daniel G. Nocera. 2015. “Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies Asin VivoTwo-Photon Oxygen Sensors.” Journal of the American Chemical Society 137 (31) (August 12): 9832–9842. doi:10.1021/jacs.5b04765.Abstract
Micelles have been employed to encapsulate the supramolecular assembly of quantum dots with palladium(II) porphyrins for the quantification of O2 levels in aqueous media and in vivo. Förster resonance energy transfer from the quantum dot (QD) to the palladium porphyrin provides a means for signal transduction under both one- and two-photon excitation. The palladium porphyrins are sensitive to O2 concentrations in the range of 0–160 Torr. The micelle-encapsulated QD-porphyrin assemblies have been employed for in vivo multiphoton imaging and lifetime-based oxygen measurements in mice with chronic dorsal skinfold chambers or cranial windows. Our results establish the utility of the QD-micelle approach for in vivo biological sensing applications.Other Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26149349/Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAPCitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:33464249
Collections
- FAS Scholarly Articles [18292]
Contact administrator regarding this item (to report mistakes or request changes)