3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

Abstract

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new ­avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.