Hooker, Jacob M., Matthias Schönberger, Hanno Schieferstein, and Joanna S. Fowler. 2008. “A Simple, Rapid Method for the Preparation of [11C]Formaldehyde.” Angewandte Chemie International Edition 47 (32) (July 4): 5989–5992. doi:10.1002/anie.200800991.
A PET project: A powerful reagent for the synthesis of positron-emitting imaging molecules—[11C]formaldehyde—is accessible from [11C]methyl iodide and trimethylamine N-oxide (TMAO) in high yields and under mild conditions. Easy access to [11C]formaldehyde expands the scope of the carbon-11 toolbox and will lead to new reaction methodology and imaging compounds.