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dc.contributor.authorHo, N F
dc.contributor.authorHooker, Jacob M
dc.contributor.authorSahay, Amar
dc.contributor.authorHolt, Daphne Jane
dc.contributor.authorRoffman, Joshua Lawrence
dc.date.accessioned2017-07-24T17:15:53Z
dc.date.issued2013
dc.identifier.citationHo, N F, J M Hooker, A Sahay, D J Holt, and J L Roffman. 2013. “In Vivo Imaging of Adult Human Hippocampal Neurogenesis: Progress, Pitfalls and Promise.” Molecular Psychiatry 18 (4) (February 26): 404–416. doi:10.1038/mp.2013.8.en_US
dc.identifier.issn1359-4184en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33490454
dc.description.abstractNew neurons are produced within the hippocampus of the mammalian brain throughout life. Evidence from animal studies has suggested that the function of these adult-born neurons is linked to cognition and emotion. Until we are able to detect and measure levels of adult neurogenesis in living human brains—a formidable challenge for now—we cannot establish its functional importance in human health, disease and new treatment development. Current non-invasive neuroimaging modalities can provide live snapshots of the brain’s structure, chemistry, activity and connectivity. This review explores whether existing macroscopic imaging methods can be used to understand the microscopic dynamics of adult hippocampal neurogenesis in living individuals. We discuss recent studies that have found correlations between neuroimaging measures of human hippocampal biology and levels of pro- or anti-neurogenic stimuli, weigh whether these correlations reflect changes in adult neurogenesis, detail the conceptual and technical limitations of these studies and elaborate on what will be needed to validate in vivo neuroimaging measures of adult neurogenesis for future investigations.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isversionofdoi:10.1038/mp.2013.8en_US
dash.licenseMETA_ONLY
dc.subjectadult human hippocampal neurogenesisen_US
dc.subjectin vivo neuroimagingen_US
dc.titleIn Vivo Imaging of Adult Human Hippocampal Neurogenesis: Progress, Pitfalls and Promiseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalMolecular Psychiatryen_US
dash.depositing.authorHooker, Jacob M
dash.embargo.until10000-01-01
dc.identifier.doi10.1038/mp.2013.8*
workflow.legacycommentsHooker emailed 2016-05-15 MM Hooker emailed 2017-02-26 MM meta.darken_US
dash.contributor.affiliatedHolt, Daphne
dash.contributor.affiliatedSahay, Amar
dash.contributor.affiliatedRoffman, Joshua
dash.contributor.affiliatedHooker, Jacob


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