Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients

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Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients

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dc.contributor.author Lee, Mei-Hsuan en_US
dc.contributor.author Huang, Chung-Feng en_US
dc.contributor.author Lai, Hsueh-Chou en_US
dc.contributor.author Lin, Chun-Yen en_US
dc.contributor.author Dai, Chia-Yen en_US
dc.contributor.author Liu, Chun-Jen en_US
dc.contributor.author Wang, Jing-Houng en_US
dc.contributor.author Huang, Jee-Fu en_US
dc.contributor.author Su, Wen-Pang en_US
dc.contributor.author Yang, Hung-Chih en_US
dc.contributor.author Kee, Kwong-Ming en_US
dc.contributor.author Yeh, Ming-Lun en_US
dc.contributor.author Chuang, Po-Heng en_US
dc.contributor.author Hsu, Shih-Jer en_US
dc.contributor.author Huang, Ching-I en_US
dc.contributor.author Kao, Jung-Ta en_US
dc.contributor.author Chen, Chieh-Chang en_US
dc.contributor.author Chen, Sheng-Hung en_US
dc.contributor.author Jeng, Wen-Juei en_US
dc.contributor.author Yang, Hwai-I en_US
dc.contributor.author Yuan, Yong en_US
dc.contributor.author Lu, Sheng-Nan en_US
dc.contributor.author Sheen, I-Shyan en_US
dc.contributor.author Liu, Chen-Hua en_US
dc.contributor.author Peng, Cheng-Yuan en_US
dc.contributor.author Kao, Jia-Horng en_US
dc.contributor.author Yu, Ming-Lung en_US
dc.contributor.author Chuang, Wan-Long en_US
dc.contributor.author Chen, Chien-Jen en_US
dc.date.accessioned 2017-07-24T18:33:20Z
dc.date.issued 2017 en_US
dc.identifier.citation Lee, M., C. Huang, H. Lai, C. Lin, C. Dai, C. Liu, J. Wang, et al. 2017. “Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients.” Scientific Reports 7 (1): 3718. doi:10.1038/s41598-017-02313-y. http://dx.doi.org/10.1038/s41598-017-02313-y. en
dc.identifier.issn en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490704
dc.description.abstract This follow-up study enrolled chronic hepatitis C patients to evaluate the treatment efficacy and to identify post-treatment seromarkers associated with risk of hepatocellular carcinoma (HCC) among patients with a sustained virological response (SVR) or nonsustained virological response (NSVR). A total of 4639 patients who received pegylated interferon and ribavirin during 2004–2013 were followed until December 2014. HCC was confirmed through health examinations and data linkage with a national database. A total of 233 HCC cases were reported after 26,163 person-years of follow-up, indicating an incidence of 8.9 per 1000 person-years: 6.9 for SVR and 21.6 for NSVR per 1000 person-years. The associated risk of HCC in patients with SVR was 0.37 (0.22–0.63) for those without cirrhosis and 0.54 (0.31–0.92) for those with cirrhosis compared with their respective counterparts with NSVR. Among patients with SVR, advanced age, male gender, cirrhosis, decreased platelet count, and increased aspartate aminotransferase and α-fetoprotein levels were associated with HCC (p < 0.001). The treatment of chronic hepatitis C patients before they developed cirrhosis showed a higher efficacy than did the treatment of those who had already developed cirrhosis. Patients with SVR may still have a risk of HCC and need to be regularly monitored. en
dc.language.iso en_US en
dc.publisher Nature Publishing Group UK en
dc.relation.isversionof doi:10.1038/s41598-017-02313-y en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473811/pdf/ en
dash.license LAA en_US
dc.title Clinical Efficacy and Post-Treatment Seromarkers Associated with the Risk of Hepatocellular Carcinoma among Chronic Hepatitis C Patients en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Scientific Reports en
dash.depositing.author Yu, Ming-Lung en_US
dc.date.available 2017-07-24T18:33:20Z

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