Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

DSpace/Manakin Repository

Characterization of TauC3 antibody and demonstration of its potential to block tau propagation

Citable link to this page

 

 
Title: Characterization of TauC3 antibody and demonstration of its potential to block tau propagation
Author: Nicholls, Samantha B.; DeVos, Sarah L.; Commins, Caitlin; Nobuhara, Chloe; Bennett, Rachel E.; Corjuc, Diana L.; Maury, Eduardo; Eftekharzadeh, Bahareh; Akingbade, Ololade; Fan, Zhanyun; Roe, Allyson D.; Takeda, Shuko; Wegmann, Susanne; Hyman, Bradley T.

Note: Order does not necessarily reflect citation order of authors.

Citation: Nicholls, S. B., S. L. DeVos, C. Commins, C. Nobuhara, R. E. Bennett, D. L. Corjuc, E. Maury, et al. 2017. “Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.” PLoS ONE 12 (5): e0177914. doi:10.1371/journal.pone.0177914. http://dx.doi.org/10.1371/journal.pone.0177914.
Full Text & Related Files:
Abstract: The spread of neurofibrillary tangle (NFT) pathology through the human brain is a hallmark of Alzheimer’s disease (AD), which is thought to be caused by the propagation of “seeding” competent soluble misfolded tau. “TauC3”, a C-terminally truncated form of tau that is generated by caspase-3 cleavage at D421, has previously been observed in NFTs and has been implicated in tau toxicity. Here we show that TauC3 is found in the seeding competent high molecular weight (HMW) protein fraction of human AD brain. Using a specific TauC3 antibody, we were able to substantially block the HMW tau seeding activity of human AD brain extracts in an in vitro tau seeding FRET assay. We propose that TauC3 could contribute to the templated tau misfolding that leads to NFT spread in AD brains.
Published Version: doi:10.1371/journal.pone.0177914
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439699/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490775
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters