Association of increased Treg and Th17 with pathogenesis of moyamoya disease

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Association of increased Treg and Th17 with pathogenesis of moyamoya disease

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Title: Association of increased Treg and Th17 with pathogenesis of moyamoya disease
Author: Weng, Leihua; Cao, Xiang; Han, Lijuan; Zhao, Haoran; Qiu, Shuwei; Yan, Yaping; Wang, Xiaoying; Chen, Xiangyan; Zheng, Weihong; Xu, Xin; Gao, Yuanyuan; Chen, Yan; Li, Jie; Yang, Yongbo; Xu, Yun

Note: Order does not necessarily reflect citation order of authors.

Citation: Weng, L., X. Cao, L. Han, H. Zhao, S. Qiu, Y. Yan, X. Wang, et al. 2017. “Association of increased Treg and Th17 with pathogenesis of moyamoya disease.” Scientific Reports 7 (1): 3071. doi:10.1038/s41598-017-03278-8. http://dx.doi.org/10.1038/s41598-017-03278-8.
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Abstract: Immuno-inflammation has been shown to play a pivotal role in the pathogenesis of moyamoya disease (MMD). However, how did circulating Treg/Th17 cells involve in MMD patients remains unclear. 26 MMD, 21 atherothrombotic stroke, and 32 healthy controls were enrolled in this study. MMD patients have a significantly higher percentage of circulating Treg and Th17 cells as well as their dominantly secreting cytokines than other groups (P < 0.0001), whereas no difference was found in the ratio of Treg/Th17 between patients in MMD and atherothrombotic stroke group or control subjects (P = 0.244). However, the increased Treg in MMD patients which were enriched with FrIII Treg cells had deficient suppressive functions (P = 0.0017) compared to healthy volunteers. There was a positive correlation between Treg or TGF-β and MMD Suzuki’s stage. And the level of circulating Treg was as an independent factor associated with MMD stage. Besides, TGF-β was also correlated with the increased expression of VEGF in MMD patients. Our findings indicated an important involvement of circulating Treg in the pathogenic development of MMD and TGF-β in Treg induced VEGF.
Published Version: doi:10.1038/s41598-017-03278-8
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465197/pdf/
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Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490858
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