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dc.contributor.authorWeng, Leihuaen_US
dc.contributor.authorCao, Xiangen_US
dc.contributor.authorHan, Lijuanen_US
dc.contributor.authorZhao, Haoranen_US
dc.contributor.authorQiu, Shuweien_US
dc.contributor.authorYan, Yapingen_US
dc.contributor.authorWang, Xiaoyingen_US
dc.contributor.authorChen, Xiangyanen_US
dc.contributor.authorZheng, Weihongen_US
dc.contributor.authorXu, Xinen_US
dc.contributor.authorGao, Yuanyuanen_US
dc.contributor.authorChen, Yanen_US
dc.contributor.authorLi, Jieen_US
dc.contributor.authorYang, Yongboen_US
dc.contributor.authorXu, Yunen_US
dc.date.accessioned2017-07-24T18:34:33Z
dc.date.issued2017en_US
dc.identifier.citationWeng, L., X. Cao, L. Han, H. Zhao, S. Qiu, Y. Yan, X. Wang, et al. 2017. “Association of increased Treg and Th17 with pathogenesis of moyamoya disease.” Scientific Reports 7 (1): 3071. doi:10.1038/s41598-017-03278-8. http://dx.doi.org/10.1038/s41598-017-03278-8.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33490858
dc.description.abstractImmuno-inflammation has been shown to play a pivotal role in the pathogenesis of moyamoya disease (MMD). However, how did circulating Treg/Th17 cells involve in MMD patients remains unclear. 26 MMD, 21 atherothrombotic stroke, and 32 healthy controls were enrolled in this study. MMD patients have a significantly higher percentage of circulating Treg and Th17 cells as well as their dominantly secreting cytokines than other groups (P < 0.0001), whereas no difference was found in the ratio of Treg/Th17 between patients in MMD and atherothrombotic stroke group or control subjects (P = 0.244). However, the increased Treg in MMD patients which were enriched with FrIII Treg cells had deficient suppressive functions (P = 0.0017) compared to healthy volunteers. There was a positive correlation between Treg or TGF-β and MMD Suzuki’s stage. And the level of circulating Treg was as an independent factor associated with MMD stage. Besides, TGF-β was also correlated with the increased expression of VEGF in MMD patients. Our findings indicated an important involvement of circulating Treg in the pathogenic development of MMD and TGF-β in Treg induced VEGF.en
dc.language.isoen_USen
dc.publisherNature Publishing Group UKen
dc.relation.isversionofdoi:10.1038/s41598-017-03278-8en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465197/pdf/en
dash.licenseLAAen_US
dc.titleAssociation of increased Treg and Th17 with pathogenesis of moyamoya diseaseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorWang, Xiaoyingen_US
dc.date.available2017-07-24T18:34:33Z
dc.identifier.doi10.1038/s41598-017-03278-8*
dash.authorsorderedfalse
dash.contributor.affiliatedWang, Xiaoying


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