Association of increased Treg and Th17 with pathogenesis of moyamoya disease

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Association of increased Treg and Th17 with pathogenesis of moyamoya disease

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dc.contributor.author Weng, Leihua en_US
dc.contributor.author Cao, Xiang en_US
dc.contributor.author Han, Lijuan en_US
dc.contributor.author Zhao, Haoran en_US
dc.contributor.author Qiu, Shuwei en_US
dc.contributor.author Yan, Yaping en_US
dc.contributor.author Wang, Xiaoying en_US
dc.contributor.author Chen, Xiangyan en_US
dc.contributor.author Zheng, Weihong en_US
dc.contributor.author Xu, Xin en_US
dc.contributor.author Gao, Yuanyuan en_US
dc.contributor.author Chen, Yan en_US
dc.contributor.author Li, Jie en_US
dc.contributor.author Yang, Yongbo en_US
dc.contributor.author Xu, Yun en_US
dc.date.accessioned 2017-07-24T18:34:33Z
dc.date.issued 2017 en_US
dc.identifier.citation Weng, L., X. Cao, L. Han, H. Zhao, S. Qiu, Y. Yan, X. Wang, et al. 2017. “Association of increased Treg and Th17 with pathogenesis of moyamoya disease.” Scientific Reports 7 (1): 3071. doi:10.1038/s41598-017-03278-8. http://dx.doi.org/10.1038/s41598-017-03278-8. en
dc.identifier.issn en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490858
dc.description.abstract Immuno-inflammation has been shown to play a pivotal role in the pathogenesis of moyamoya disease (MMD). However, how did circulating Treg/Th17 cells involve in MMD patients remains unclear. 26 MMD, 21 atherothrombotic stroke, and 32 healthy controls were enrolled in this study. MMD patients have a significantly higher percentage of circulating Treg and Th17 cells as well as their dominantly secreting cytokines than other groups (P < 0.0001), whereas no difference was found in the ratio of Treg/Th17 between patients in MMD and atherothrombotic stroke group or control subjects (P = 0.244). However, the increased Treg in MMD patients which were enriched with FrIII Treg cells had deficient suppressive functions (P = 0.0017) compared to healthy volunteers. There was a positive correlation between Treg or TGF-β and MMD Suzuki’s stage. And the level of circulating Treg was as an independent factor associated with MMD stage. Besides, TGF-β was also correlated with the increased expression of VEGF in MMD patients. Our findings indicated an important involvement of circulating Treg in the pathogenic development of MMD and TGF-β in Treg induced VEGF. en
dc.language.iso en_US en
dc.publisher Nature Publishing Group UK en
dc.relation.isversionof doi:10.1038/s41598-017-03278-8 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465197/pdf/ en
dash.license LAA en_US
dc.title Association of increased Treg and Th17 with pathogenesis of moyamoya disease en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Scientific Reports en
dash.depositing.author Wang, Xiaoying en_US
dc.date.available 2017-07-24T18:34:33Z

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