MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer

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MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer

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Title: MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
Author: Godlewski, Jakub; Ferrer-Luna, Ruben; Rooj, Arun K.; Mineo, Marco; Ricklefs, Franz; Takeda, Yuji S.; Nowicki, M. Oskar; Salińska, Elżbieta; Nakano, Ichiro; Lee, Hakho; Weissleder, Ralph; Beroukhim, Rameen; Chiocca, E. Antonio; Bronisz, Agnieszka

Note: Order does not necessarily reflect citation order of authors.

Citation: Godlewski, J., R. Ferrer-Luna, A. K. Rooj, M. Mineo, F. Ricklefs, Y. S. Takeda, M. O. Nowicki, et al. 2017. “MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.” Stem Cell Reports 8 (6): 1497-1505. doi:10.1016/j.stemcr.2017.04.024. http://dx.doi.org/10.1016/j.stemcr.2017.04.024.
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Abstract: Summary Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.
Published Version: doi:10.1016/j.stemcr.2017.04.024
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470095/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490876
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