MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer
Takeda, Yuji S.
Nowicki, M. Oskar
MetadataShow full item record
CitationGodlewski, J., R. Ferrer-Luna, A. K. Rooj, M. Mineo, F. Ricklefs, Y. S. Takeda, M. O. Nowicki, et al. 2017. “MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.” Stem Cell Reports 8 (6): 1497-1505. doi:10.1016/j.stemcr.2017.04.024. http://dx.doi.org/10.1016/j.stemcr.2017.04.024.
AbstractSummary Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33490876
- HMS Scholarly Articles