Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences
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Author
Price, D.
Tyler, L. K.
Neto Henriques, R.
Campbell, K. L.
Williams, N.
Treder, M.S.
Taylor, J. R.
Brayne, Carol
Bullmore, Edward T.
Calder, Andrew C.
Cusack, Rhodri
Dalgleish, Tim
Duncan, John
Matthews, Fiona E.
Marslen-Wilson, William D.
Rowe, James B.
Shafto, Meredith A.
Cheung, Teresa
Davis, Simon
Geerligs, Linda
Kievit, Rogier
McCarrey, Anna
Mustafa, Abdur
Samu, David
Tsvetanov, Kamen A.
van Belle, Janna
Bates, Lauren
Emery, Tina
Erzinglioglu, Sharon
Gadie, Andrew
Gerbase, Sofia
Georgieva, Stanimira
Hanley, Claire
Parkin, Beth
Troy, David
Auer, Tibor
Correia, Marta
Gao, Lu
Green, Emma
Allen, Jodie
Amery, Gillian
Amunts, Liana
Barcroft, Anne
Castle, Amanda
Dias, Cheryl
Dowrick, Jonathan
Fair, Melissa
Fisher, Hayley
Goulding, Anna
Grewal, Adarsh
Hale, Geoff
Hilton, Andrew
Johnson, Frances
Johnston, Patricia
Kavanagh-Williamson, Thea
Kwasniewska, Magdalena
McMinn, Alison
Norman, Kim
Penrose, Jessica
Roby, Fiona
Rowland, Diane
Sargeant, John
Squire, Maggie
Stevens, Beth
Stoddart, Aldabra
Stone, Cheryl
Thompson, Tracy
Yazlik, Ozlem
Barnes, Dan
Dixon, Marie
Hillman, Jaya
Mitchell, Joanne
Villis, Laura
Henson, R. N. A.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms15671Metadata
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Price, D., L. K. Tyler, R. Neto Henriques, K. L. Campbell, N. Williams, M. Treder, J. R. Taylor, et al. 2017. “Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences.” Nature Communications 8 (1): 15671. doi:10.1038/ncomms15671. http://dx.doi.org/10.1038/ncomms15671.Abstract
Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472747/pdf/Terms of Use
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