‘Mom—I don’t want to hear it’: Brain response to maternal praise and criticism in adolescents with major depressive disorder

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‘Mom—I don’t want to hear it’: Brain response to maternal praise and criticism in adolescents with major depressive disorder

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Title: ‘Mom—I don’t want to hear it’: Brain response to maternal praise and criticism in adolescents with major depressive disorder
Author: Silk, Jennifer S.; Lee, Kyung Hwa; Elliott, Rosalind D.; Hooley, Jill M.; Dahl, Ronald E.; Barber, Anita; Siegle, Greg J.

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Citation: Silk, Jennifer S., Kyung Hwa Lee, Rosalind D. Elliott, Jill M. Hooley, Ronald E. Dahl, Anita Barber, and Greg J. Siegle. 2017. “‘Mom—I don’t want to hear it’: Brain response to maternal praise and criticism in adolescents with major depressive disorder.” Social Cognitive and Affective Neuroscience 12 (5): 729-738. doi:10.1093/scan/nsx014. http://dx.doi.org/10.1093/scan/nsx014.
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Abstract: Abstract Recent research has implicated altered neural response to interpersonal feedback as an important factor in adolescent depression, with existing studies focusing on responses to feedback from virtual peers. We investigated whether depressed adolescents differed from healthy youth in neural response to social evaluative feedback from mothers. During neuroimaging, twenty adolescents in a current episode of major depressive disorder (MDD) and 28 healthy controls listened to previously recorded audio clips of their own mothers’ praise, criticism and neutral comments. Whole-brain voxelwise analyses revealed that MDD youth, unlike controls, exhibited increased neural response to critical relative to neutral clips in the parahippocampal gyrus, an area involved in episodic memory encoding and retrieval. Depressed adolescents also showed a blunted response to maternal praise clips relative to neutral clips in the parahippocampal gyrus, as well as areas involved in reward and self-referential processing (i.e. ventromedial prefrontal cortex, precuneus, and thalamus/caudate). Findings suggest that maternal criticism may be more strongly encoded or more strongly activated during memory retrieval related to previous autobiographical instances of negative feedback from mothers in depressed youth compared to healthy youth. Furthermore, depressed adolescents may fail to process the reward value and self-relevance of maternal praise.
Published Version: doi:10.1093/scan/nsx014
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460041/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490937
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