Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium
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Author
Cannioto, Rikki A
LaMonte, Michael J
Kelemen, Linda E
Risch, Harvey A
Eng, Kevin H
Minlikeeva, Albina N
Hong, Chi-Chen
Szender, J Brian
Sucheston-Campbell, Lara
Joseph, Janine M
Berchuck, Andrew
Chang-Claude, Jenny
DeFazio, Anna
Diergaarde, Brenda
Dörk, Thilo
Doherty, Jennifer A
Edwards, Robert P
Fridley, Brooke L
Friel, Grace
Goode, Ellen L
Goodman, Marc T
Hillemanns, Peter
Hogdall, Estrid
Hosono, Satoyo
Kelley, Joseph L
Kjaer, Susanne K
Klapdor, Rüdiger
Matsuo, Keitaro
Odunsi, Kunle
Nagle, Christina M
Olsen, Catherine M
Paddock, Lisa E
Pearce, Celeste L
Pike, Malcolm C
Rossing, Mary A
Schmalfeldt, Barbara
Segal, Brahm H
Szamreta, Elizabeth A
Thompson, Pamela J
Tseng, Chiu-Chen
Vierkant, Robert
Schildkraut, Joellen M
Wentzensen, Nicolas
Wicklund, Kristine G
Winham, Stacey J
Wu, Anna H
Modugno, Francesmary
Ness, Roberta B
Jensen, Allan
Webb, Penelope M
Bandera, Elisa V
Moysich, Kirsten B
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/bjc.2016.153Metadata
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Cannioto, R. A., M. J. LaMonte, L. E. Kelemen, H. A. Risch, K. H. Eng, A. N. Minlikeeva, C. Hong, et al. 2016. “Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium.” British Journal of Cancer 115 (1): 95-101. doi:10.1038/bjc.2016.153. http://dx.doi.org/10.1038/bjc.2016.153.Abstract
Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR=1.34, 95% CI: 1.18–1.52) and without (HR=1.22, 95% CI: 1.12–1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931371/pdf/Terms of Use
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