Eosinophils and Th2 immunity: contemporary insights

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Eosinophils and Th2 immunity: contemporary insights

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Title: Eosinophils and Th2 immunity: contemporary insights
Author: Spencer, Lisa Ann; Weller, Peter Fahey

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Citation: Spencer, Lisa A, and Peter F Weller. 2010. Eosinophils and Th2 Immunity: Contemporary Insights. Immunol Cell Biol 88, no. 3: 250–256. doi:10.1038/icb.2009.115.
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Abstract: Eosinophils, innate immune leukocytes elicited by Th2 cells, have long been associated with the effector arm of Th2 immune responses. However, accumulating data over the past decade reveal a much more dynamic picture of Th2 immunity, where eosinophils are present very early in response to Th2-inducing agents and function in the initiation of Th2 immunity. Here we discuss recent data showing immune functions of eosinophils distinct from their previously appreciated tissue- and helminth-destructive capacities, providing strong evidence for a new paradigm of Th2 immunity defined by a dynamic interplay between eosinophils and T cells.
Published Version: doi:10.1038/icb.2009.115
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589820/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33730188
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