Eosinophils and Th2 immunity: contemporary insights
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CitationSpencer, Lisa A, and Peter F Weller. 2010. Eosinophils and Th2 Immunity: Contemporary Insights. Immunol Cell Biol 88, no. 3: 250–256. doi:10.1038/icb.2009.115.
AbstractEosinophils, innate immune leukocytes elicited by Th2 cells, have long been associated with the effector arm of Th2 immune responses. However, accumulating data over the past decade reveal a much more dynamic picture of Th2 immunity, where eosinophils are present very early in response to Th2-inducing agents and function in the initiation of Th2 immunity. Here we discuss recent data showing immune functions of eosinophils distinct from their previously appreciated tissue- and helminth-destructive capacities, providing strong evidence for a new paradigm of Th2 immunity defined by a dynamic interplay between eosinophils and T cells.
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