Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils

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Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils

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Title: Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils
Author: Melo, Rossana C.N.; Dvorak, Ann M.; Weller, Peter Fahey

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Citation: Melo, Rossana C.N., Ann M. Dvorak, and Peter F. Weller. 2010. Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils. Microsc Microanal 16, no. 6: 653–660. doi:10.1017/s1431927610093864.
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Abstract: Mechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. In response to varied stimuli, eosinophils are recruited from the circulation into inflammatory foci, where they modulate immune responses through the release of granule-derived products. Transmission electron microscopy (TEM) is the only technique that can clearly identify and distinguish between different modes of cell secretion. In this review, we highlight the advances in understanding mechanisms of eosinophil secretion, based on TEM findings, that have been made over the past years and that have provided unprecedented insights into the functional capabilities of these cells.
Published Version: doi:10.1017/S1431927610093864
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420811/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33730191
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