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dc.contributor.authorMelo, Rossana C.N.
dc.contributor.authorDvorak, Ann M.
dc.contributor.authorWeller, Peter Fahey
dc.date.accessioned2017-08-09T15:06:03Z
dc.date.issued2010
dc.identifier.citationMelo, Rossana C.N., Ann M. Dvorak, and Peter F. Weller. 2010. Contributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophils. Microsc Microanal 16, no. 6: 653–660. doi:10.1017/s1431927610093864.en_US
dc.identifier.issn1431-9276en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33730191
dc.description.abstractMechanisms governing secretion of proteins underlie the biologic activities and functions of human eosinophils, leukocytes of the innate immune system, involved in allergic, inflammatory, and immunoregulatory responses. In response to varied stimuli, eosinophils are recruited from the circulation into inflammatory foci, where they modulate immune responses through the release of granule-derived products. Transmission electron microscopy (TEM) is the only technique that can clearly identify and distinguish between different modes of cell secretion. In this review, we highlight the advances in understanding mechanisms of eosinophil secretion, based on TEM findings, that have been made over the past years and that have provided unprecedented insights into the functional capabilities of these cells.en_US
dc.language.isoen_USen_US
dc.publisherCambridge University Press (CUP)en_US
dc.relation.isversionofdoi:10.1017/S1431927610093864en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420811/en_US
dash.licenseLAA
dc.titleContributions of Electron Microscopy to Understand Secretion of Immune Mediators by Human Eosinophilsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalMicroscopy and Microanalysisen_US
dash.depositing.authorWeller, Peter Fahey
dc.date.available2017-08-09T15:06:03Z
dc.identifier.doi10.1017/S1431927610093864*
dash.contributor.affiliatedWeller, Peter


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