Delirium is associated with early postoperative cognitive dysfunction

View/ Open
Author
Silverstein, J. H.
Rasmussen, L. S.
Published Version
https://doi.org/10.1111/j.1365-2044.2008.05523.xMetadata
Show full item recordCitation
Rudolph, J. L., E. R. Marcantonio, D. J. Culley, J. H. Silverstein, L. S. Rasmussen, G. J. Crosby, and S. K. Inouye. 2008. “Delirium Is Associated with Early Postoperative Cognitive Dysfunction.” Anaesthesia 63 (9) (June 10): 941–947. doi:10.1111/j.1365-2044.2008.05523.x.Abstract
The purpose of this analysis was to determine if postoperative delirium was associated with early postoperative cognitive dysfunction (at 7 days) and long-term postoperative cognitive dysfunction (at 3 months). The International Study of Postoperative Cognitive Dysfunction recruited 1218 subjects ≥ 60 years old undergoing elective, non-cardiac surgery. Postoperatively, subjects were evaluated for delirium using the criteria of the Diagnostic and Statistical Manual. Subjects underwent neuropsychological testing pre-operatively and postoperatively at 7 days (n = 1018) and 3 months (n = 946). Postoperative cognitive dysfunction was defined as a composite Z-score > 2 across tests or at least two individual test Z-scores > 2. Subjects with delirium were significantly less likely to participate in postoperative testing. Delirium was associated with an increased incidence of early postoperative cognitive dysfunction (adjusted risk ratio 1.6, 95% CI 1.1–2.1), but not long-term postoperative cognitive dysfunction (adjusted risk ratio 1.3, 95% CI 0.6–2.4). Delirium was associated with early postoperative cognitive dysfunction, but the relationship of delirium to long-term postoperative cognitive dysfunction remains unclear.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562627/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:33749601
Collections
- HMS Scholarly Articles [17714]
Contact administrator regarding this item (to report mistakes or request changes)