Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?

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Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?

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Title: Association cortex hypoperfusion in mild dementia with Lewy bodies: a potential indicator of cholinergic dysfunction?
Author: Fong, Tamara G; Inouye, Sharon; Dai, Weiying; Press, Daniel; Alsop, David C.

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Citation: Fong, Tamara G., Sharon K. Inouye, Weiying Dai, Daniel Z. Press, and David C. Alsop. 2010. “Association Cortex Hypoperfusion in Mild Dementia with Lewy Bodies: a Potential Indicator of Cholinergic Dysfunction?” Brain Imaging and Behavior 5 (1) (October 6): 25–35. doi:10.1007/s11682-010-9108-x.
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Abstract: Dementia with Lewy bodies (DLB) is often associated with occipital hypometabolism or hypoperfusion, as well as deficits in cholinergic neurotransmission. In this study, 11 mild DLB, 16 mild AD and 16 age-matched controls underwent arterial spin-labeled perfusion MRI (ASL-pMRI) and neuropsychological testing. Patterns of cerebral blood flow (CBF) and cognitive performance were compared. In addition, combined ASL-pMRI and ChEI drug challenge (pharmacologic MRI) was tested as a probe of cholinergic function in 4 of the DLB participants. Frontal and parieto-occipital hypoperfusion was observed in both DLB and AD but was more pronounced in DLB. Following ChEI treatment, perfusion increased in temporal and parieto-occipital cortex, and cognitive performance improved on a verbal fluency task. If confirmed in a larger study, these results provide further evidence for brain cholinergic dysfunction in DLB pathophysiology, and use of pharmacologic MRI as an in vivo measure of cholinergic function.
Published Version: doi:10.1007/s11682-010-9108-x
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/20924800
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33750342
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