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dc.contributor.authorRudolph, James
dc.contributor.authorInouye, Sharon
dc.contributor.authorJones, Richard N.
dc.contributor.authorYang, Frances Margaret
dc.contributor.authorFong, Tamara G
dc.contributor.authorLevkoff, Sue E.
dc.contributor.authorMarcantonio, Edward Ralph
dc.date.accessioned2017-08-15T16:17:59Z
dc.date.issued2010
dc.identifierQuick submit: 2014-12-19T22:39:05-05:00
dc.identifier.citationRudolph, James L., Sharon K. Inouye, Richard N. Jones, Frances M. Yang, Tamara G. Fong, Sue E. Levkoff, and Edward R. Marcantonio. 2010. “Delirium: An Independent Predictor of Functional Decline After Cardiac Surgery.” Journal of the American Geriatrics Society 58 (4) (March 22): 643–649. doi:10.1111/j.1532-5415.2010.02762.x.en_US
dc.identifier.issn0002-8614en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33750344
dc.description.abstractOBJECTIVES: To determine whether patients who developed delirium after cardiac surgery were at risk of functional decline. DESIGN: Prospective cohort study. SETTING: Two academic hospitals and a Veterans Affairs Medical Center. PARTICIPANTS: One hundred ninety patients aged 60 and older undergoing elective or urgent cardiac surgery. MEASUREMENTS: Delirium was assessed daily and was diagnosed according to the Confusion Assessment Method. Before surgery and 1 and 12 months postoperatively, patients were assessed for function using the instrumental activities of daily living (IADL) scale. Functional decline was defined as a decrease in ability to perform one IADL at follow-up. RESULTS: Delirium occurred in 43.1% (n=82) of the patients (mean age 73.7±6.7). Functional decline occurred in 36.3% (n=65/179) at 1 month and in 14.6% (n=26/178) at 12 months. Delirium was associated with greater risk of functional decline at 1 month (relative risk (RR)=1.9, 95% confidence interval (CI)=1.3–2.8) and tended toward greater risk at 12 months (RR=1.9, 95% CI=0.9–3.8). After adjustment for age, cognition, comorbidity, and baseline function, delirium remained significantly associated with functional decline at 1 month (adjusted RR=1.8, 95% CI=1.2–2.6) but not at 12 months (adjusted RR=1.5, 95% CI=0.6–3.3). CONCLUSION: Delirium was independently associated with functional decline at 1 month and had a trend toward association at 12 months. These findings provide justification for intervention trials to evaluate whether delirium prevention or treatment strategies might improve postoperative functional recovery.en_US
dc.language.isoen_USen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionofdoi:10.1111/j.1532-5415.2010.02762.xen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/20345866en_US
dash.licenseLAA
dc.subjectdeliriumen_US
dc.subjectfunctionen_US
dc.subjectcardiac surgeryen_US
dc.subjectageden_US
dc.subjectinstrumental activities of daily livingen_US
dc.titleDelirium: An Independent Predictor of Functional Decline After Cardiac Surgeryen_US
dc.typeJournal Articleen_US
dc.date.updated2014-12-20T03:39:05Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderRudolph JL, Inouye SK, Jones RN, Yang FM, Fong TG, Levkoff SE, Marcantonio ER
dc.relation.journalJournal of the American Geriatrics Societyen_US
dash.depositing.authorInouye, Sharon
dc.date.available2017-08-15T16:17:59Z
dc.identifier.doi10.1111/j.1532-5415.2010.02762.x*
dash.contributor.affiliatedYang, Frances Margaret
dash.contributor.affiliatedFong, Tamara
dash.contributor.affiliatedLevkoff, Sue
dash.contributor.affiliatedRudolph, James
dash.contributor.affiliatedMarcantonio, Edward
dash.contributor.affiliatedInouye, Sharon


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