Show simple item record

dc.contributor.authorHshieh, Tammy Ting
dc.contributor.authorFong, Tamara G
dc.contributor.authorMarcantonio, Edward Ralph
dc.contributor.authorInouye, Sharon
dc.date.accessioned2017-08-15T16:27:12Z
dc.date.issued2008
dc.identifierQuick submit: 2014-12-19T22:15:45-05:00
dc.identifier.citationHshieh, T. T., T. G. Fong, E. R. Marcantonio, and S. K. Inouye. 2008. “Cholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidence.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63 (7) (July 1): 764–772. doi:10.1093/gerona/63.7.764.en_US
dc.identifier.issn1079-5006en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33750350
dc.description.abstractDeficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on potential pathophysiological pathways. Acetylcholine synthesis involves various precursors, enzymes, and receptors, and dysfunction in these components can lead to delirium. Insults to the brain, like ischemia and immunological stressors, can precipitously alter acetylcholine levels. Imbalances between cholinergic and other neurotransmitter pathways may result in delirium. Furthermore, genetic, enzymatic, and immunological overlaps exist between delirium and dementia related to the cholinergic pathway. Important areas for future research include identifying biomarkers, determining genetic contributions, and evaluating response to cholinergic drugs in delirium. Understanding how the cholinergic pathway relates to delirium may yield innovative approaches in the diagnosis, prevention, and treatment of this common, costly, and morbid condition.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.isversionofdoi:10.1093/gerona/63.7.764en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/18693233en_US
dash.licenseLAA
dc.subjectCholinergic deficiencyen_US
dc.subjectDementiaen_US
dc.subjectDelirium in older personsen_US
dc.subjectDeliriumen_US
dc.subjectAcetylcholineen_US
dc.titleCholinergic Deficiency Hypothesis in Delirium: A Synthesis of Current Evidenceen_US
dc.typeJournal Articleen_US
dc.date.updated2014-12-20T03:15:45Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderHshieh TT, Fong TG, Marcantonio ER, Inouye SK
dc.relation.journalThe Journals of Gerontology Series A: Biological Sciences and Medical Sciencesen_US
dash.depositing.authorInouye, Sharon
dc.date.available2017-08-15T16:27:12Z
dc.identifier.doi10.1093/gerona/63.7.764*
dash.contributor.affiliatedHshieh, Tammy
dash.contributor.affiliatedFong, Tamara
dash.contributor.affiliatedMarcantonio, Edward
dash.contributor.affiliatedInouye, Sharon


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record