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dc.contributor.authorVelasquez, Gustavo Eduardo
dc.contributor.authorCegielski, J. Peter
dc.contributor.authorMurray, Megan Blanche
dc.contributor.authorYagui, Martin J. A.
dc.contributor.authorAsencios, Luis L.
dc.contributor.authorBayona, Jaime
dc.contributor.authorBonilla, Cesar
dc.contributor.authorJave, Hector O.
dc.contributor.authorYale, Gloria
dc.contributor.authorSuárez, Carmen Z.
dc.contributor.authorSanchez, Eduardo
dc.contributor.authorRojas, Christian
dc.contributor.authorAtwood, Sidney Sterling
dc.contributor.authorContreras, Carmen C.
dc.contributor.authorCruz, Janeth Santa
dc.contributor.authorShin, Sonya Sunhi
dc.date.accessioned2017-08-16T18:29:23Z
dc.date.issued2015
dc.identifierQuick submit: 2016-02-16T16:41:02-05:00
dc.identifier.citationVelásquez, G. E., J. P. Cegielski, M. B. Murray, M. J. A. Yagui, L. L. Asencios, J. N. Bayona, C. A. Bonilla, et al. 2015. “Impact of HIV on Mortality Among Patients Treated for Tuberculosis in Lima, Peru: a Prospective Cohort Study.” BMC Infectious Diseases 16 (1) (December). doi:10.1186/s12879-016-1375-8.en_US
dc.identifier.issn1471-2334en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33766506
dc.description.abstractBackground: Human immunodeficiency virus (HIV)-associated tuberculosis deaths have decreased worldwide over the past decade. We sought to evaluate the effect of HIV status on tuberculosis mortality among patients undergoing treatment for tuberculosis in Lima, Peru, a low HIV prevalence setting. Methods: We conducted a prospective cohort study of patients treated for tuberculosis between 2005 and 2008 in two adjacent health regions in Lima, Peru (Lima Ciudad and Lima Este). We constructed a multivariate Cox proportional hazards model to evaluate the effect of HIV status on mortality during tuberculosis treatment. Results: Of 1701 participants treated for tuberculosis, 136 (8.0 %) died during tuberculosis treatment. HIV-positive patients constituted 11.0 % of the cohort and contributed to 34.6 % of all deaths. HIV-positive patients were significantly more likely to die (25.1 vs. 5.9 %, P < 0.001) and less likely to be cured (28.3 vs. 39.4 %, P = 0.003). On multivariate analysis, positive HIV status (hazard ratio [HR] = 6.06; 95 % confidence interval [CI], 3.96–9.27), unemployment (HR = 2.24; 95 % CI, 1.55–3.25), and sputum acid-fast bacilli smear positivity (HR = 1.91; 95 % CI, 1.10–3.31) were significantly associated with a higher hazard of death. Conclusions: We demonstrate that positive HIV status was a strong predictor of mortality among patients treated for tuberculosis in the early years after Peru started providing free antiretroviral therapy. As HIV diagnosis and antiretroviral therapy provision are more widely implemented for tuberculosis patients in Peru, future operational research should document the changing profile of HIV-associated tuberculosis mortality.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Science + Business Mediaen_US
dc.relation.isversionofdoi:10.1186/s12879-016-1375-8en_US
dash.licenseLAA
dc.titleImpact of HIV on mortality among patients treated for tuberculosis in Lima, Peru: a prospective cohort studyen_US
dc.typeJournal Articleen_US
dc.date.updated2016-02-16T21:41:03Z
dc.description.versionVersion of Recorden_US
dc.rights.holderGustavo E. Velásquez,J. Peter Cegielski,Megan B. Murray,Martin J. A. Yagui, Luis L. Asencios,Jaime N. Bayona, César A. Bonilla, Hector O. Jave, Gloria Yale, Carmen Z. Suárez, Eduardo Sanchez, Christian Rojas, Sidney S. Atwood , Carmen C. Contreras, Janeth Santa Cruz and Sonya S. Shin
dc.relation.journalBMC Infect Disen_US
dash.depositing.authorMurray, Megan Blanche
dc.date.available2017-08-16T18:29:23Z
dc.identifier.doi10.1186/s12879-016-1375-8*
dash.authorsorderedfalse
dash.contributor.affiliatedVelasquez, Gustavo
dash.contributor.affiliatedAtwood, Sidney
dash.contributor.affiliatedBayona, Jaime
dash.contributor.affiliatedBonilla, Cesar
dash.contributor.affiliatedMurray, Megan
dash.contributor.affiliatedShin, Sonya


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