Internally Generated Preactivation of Single Neurons in Human Medial Frontal Cortex Predicts Volition

DSpace/Manakin Repository

Internally Generated Preactivation of Single Neurons in Human Medial Frontal Cortex Predicts Volition

Citable link to this page

 

 
Title: Internally Generated Preactivation of Single Neurons in Human Medial Frontal Cortex Predicts Volition
Author: Fried, Itzhak; Mukamel, Roy; Kreiman, Gabriel

Note: Order does not necessarily reflect citation order of authors.

Citation: Fried, Itzhak, Roy Mukamel, and Gabriel Kreiman. 2011. “Internally Generated Preactivation of Single Neurons in Human Medial Frontal Cortex Predicts Volition.” Neuron 69 (3) (February): 548–562. doi:10.1016/j.neuron.2010.11.045.
Full Text & Related Files:
Abstract: Understanding how self-initiated behavior is encoded by neuronal circuits in the human brain remains elusive. We recorded the activity of 1019 neurons while twelve subjects performed self-initiated finger movement. We report progressive neuronal recruitment over ∼1500 ms before subjects report making the decision to move. We observed progressive increase or decrease in neuronal firing rate, particularly in the supplementary motor area (SMA), as the reported time of decision was approached. A population of 256 SMA neurons is sufficient to predict in single trials the impending decision to move with accuracy greater than 80% already 700 ms prior to subjects' awareness. Furthermore, we predict, with a precision of a few hundred ms, the actual time point of this voluntary decision to move. We implement a computational model whereby volition emerges once a change in internally generated firing rate of neuronal assemblies crosses a threshold.
Published Version: doi:10.1016/j.neuron.2010.11.045
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052770/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33766513
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters