Semaphorin 3F forms an anti-angiogenic barrier in outer retina

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Semaphorin 3F forms an anti-angiogenic barrier in outer retina

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Title: Semaphorin 3F forms an anti-angiogenic barrier in outer retina
Author: Buehler, Anima; Sitaras, Nicholas; Favret, Sandra; Bucher, Felicitas; Berger, Stefanie; Pielen, Amelie; Joyal, Jean-Sebastian; Juan, Aimee M.; Martin, Gottfried; Schlunck, Guenther; Agostini, Hansjürgen T.; Klagsbrun, Michael; Smith, Lois Elaine Hodgson; Sapieha, Przemyslaw; Stahl, Andreas

Note: Order does not necessarily reflect citation order of authors.

Citation: Buehler, Anima, Nicholas Sitaras, Sandra Favret, Felicitas Bucher, Stefanie Berger, Amelie Pielen, Jean-Sebastian Joyal, et al. 2013. Semaphorin 3F Forms an Anti-Angiogenic Barrier in Outer Retina. FEBS Letters 587, no. 11: 1650–1655. doi:10.1016/j.febslet.2013.04.008.
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Abstract: Semaphorins are known modulators of axonal sprouting and angiogenesis. In the retina, we identified a distinct and almost exclusive expression of Semaphorin 3F in the outer layers. Interestingly, these outer retinal layers are physiologically avascular. Using functional in vitro models, we report potent anti-angiogenic effects of Semaphorin 3F on both retinal and choroidal vessels. In addition, human retinal pigment epithelium isolates from patients with pathologic neovascularization of the outer retina displayed reduced Semaphorin 3F expression in 10 out of 15 patients. Combined, these results elucidate a functional role for Semaphorin 3F in the outer retina where it acts as a vasorepulsive cue to maintain physiologic avascularity.
Published Version: doi:10.1016/j.febslet.2013.04.008
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