Plasma S100β is not a useful biomarker for tumor burden in neurofibromatosis
Author
Smith, Miriam J.
Esparza, Sonia
Muzikansky, Alona
Kassarjian, Ara
Mautner, Victor F.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1016/j.clinbiochem.2012.12.007Metadata
Show full item recordCitation
Smith, Miriam J., Sonia Esparza, Vanessa L. Merker, Alona Muzikansky, Miriam A. Bredella, Gordon J. Harris, Ara Kassarjian, et al. 2013. “Plasma S100? Is Not a Useful Biomarker for Tumor Burden in Neurofibromatosis.” Clinical Biochemistry 46 (7-8) (May): 698–700. doi:10.1016/j.clinbiochem.2012.12.007.Abstract
ObjectivesNeurofibromatosis 1 (NF1), NF2, and schwannomatosis are characterized by a predisposition to develop multiple neurofibromas and schwannomas. Currently, there is no blood test to estimate tumor burden in patients with these disorders. We explored whether S100β would act as a biomarker of tumor burden in NF since S100β is a classic immunohistochemical marker of astrocytes, oligodendrocytes and Schwann cells and a small study showed S100β concentrations correlate with the volume of vestibular schwannomas.
Design and methods
We calculated whole-body tumor burden in subjects with NF1, NF2, and schwannomatosis using whole-body MRI (WBMRI) and measured the concentration of S100β in plasma using ELISA. We used chi-square tests and Spearman rank correlations to test the relationship between S100β levels and whole-body tumor burden.
Results
127 consecutive patients were enrolled in the study (69 NF1 patients, 28 NF2 patients, and 30 schwannomatosis patients). The median age was 40 years, 43% were male, and median whole-body tumor volume was 26.9 mL. There was no relationship between the presence of internal tumors and the presence of detectable S100β in blood for the overall group or for individual diagnoses (p > 0.05 by chi-square for all comparisons). Similarly, there was no correlation between whole-body tumor volume and S100β concentration for the overall group or for individual diagnoses (p > 0.05 by Spearman for all comparisons).
Conclusions
Plasma S100β is not a useful biomarker for tumor burden in the neurofibromatoses. Further work is needed to identify a reliable biomarker of tumor burden in NF patients.
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