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dc.contributor.authorBehlau, Irmgard
dc.contributor.authorMukherjee, Koushik
dc.contributor.authorTodani, Amit
dc.contributor.authorTisdale, Ann S.
dc.contributor.authorCade, Fabiano
dc.contributor.authorWang, Liqiang
dc.contributor.authorLeonard, Elizabeth M.
dc.contributor.authorZakka, Fouad R.
dc.contributor.authorGilmore, Michael S.
dc.contributor.authorJakobiec, Frederick A.
dc.contributor.authorDohlman, Claes Henrik
dc.contributor.authorKlibanov, Alexander M.
dc.date.accessioned2017-09-11T19:04:10Z
dc.date.issued2011
dc.identifier.citationBehlau, Irmgard, Koushik Mukherjee, Amit Todani, Ann S. Tisdale, Fabiano Cade, Liqiang Wang, Elizabeth M. Leonard, et al. 2011. Biocompatibility and Biofilm Inhibition of N,N-Hexyl,methyl-Polyethylenimine Bonded to Boston Keratoprosthesis Materials. Biomaterials 32, no. 34: 8783–8796. doi:10.1016/j.biomaterials.2011.08.010.en_US
dc.identifier.issn0142-9612en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:33867370
dc.description.abstractThe biocompatibility and antibacterial properties of N,N-hexyl,methyl-polyethylenimine (HMPEI) covalently attached to the Boston Keratoprosthesis (B-KPro) materials was evaluated. By means of confocal and electron microscopies, we observed that HMPEI-derivatized materials exert an inhibitory effect on biofilm formation by Staphylococcus aureus clinical isolates, as compared to the parent poly(methyl methacrylate) (PMMA) and titanium. There was no additional corneal epithelial cell cytotoxicity of HMPEI-coated PMMA compared to that of control PMMA in tissue cultures in vitro. Likewise, no toxicity or adverse reactivity was detected with HMPEI-derivatized PMMA or titanium compared to those of the control materials after intrastromal or anterior chamber implantation in rabbits in vivo.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.biomaterials.2011.08.010en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410931/en_US
dash.licenseLAA
dc.subjectantibacterialen_US
dc.subjectpolyethylenimine (PEI)en_US
dc.subjectkeratoprosthesisen_US
dc.subjectPMMAen_US
dc.subjecttitaniumen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectcorneal cytotoxicityen_US
dc.titleBiocompatibility and biofilm inhibition of N,N-hexyl,methyl-polyethylenimine bonded to Boston Keratoprosthesis materialsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalBiomaterialsen_US
dash.depositing.authorGilmore, Michael S.
dc.date.available2017-09-11T19:04:10Z
dc.identifier.doi10.1016/j.biomaterials.2011.08.010*
dash.authorsorderedfalse
dash.contributor.affiliatedBehlau, Irmgard
dash.contributor.affiliatedDohlman, Claes
dash.contributor.affiliatedGilmore, Michael


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