Oxygen as a Virulence Determinant in Polymicrobial Infections

DSpace/Manakin Repository

Oxygen as a Virulence Determinant in Polymicrobial Infections

Citable link to this page

 

 
Title: Oxygen as a Virulence Determinant in Polymicrobial Infections
Author: Selleck, Elizabeth M.; Gilmore, Michael S.

Note: Order does not necessarily reflect citation order of authors.

Citation: Selleck EM, Gilmore MS.. 2016. Oxygen as a Virulence Determinant in Polymicrobial Infections. MBio. 7, no. 4. pii: e01249-16. doi: 10.1128/mBio.01249-16.
Full Text & Related Files:
Abstract: Infections caused by multiple organisms, or polymicrobial infections, are likely more common than is broadly appreciated. Interaction among microbial communities (and with their host) can change the infection landscape by subverting immunity, providing nutrients and inhibiting competing microbes. Stacy et al. (A. Stacy, D. Fleming, R. J. Lamont, K. P. Rumbaugh, and M. Whiteley, mBio 7:e00782-16, 2016, http://dx.doi.org/10.1128/mBio.00782-16) described a novel mechanism that results in synergistic growth of oral microbes Aggregatibacter actinomycetemcomitans and Streptococcus gordonii. The authors used whole-genome fitness profiling by transposon sequencing (Tn-seq) to identify genes differentially required for growth in vitro versus in a mono- or coinfection in a thigh abscess model. They found that coinfection with S. gordonii allowed A. actinomycetemcomitans to shift from an anaerobic to an aerobic mode of growth. This shift involved the production of a terminal electron acceptor H2O2 by S. gordonii and increased A. actinomycetemcomitans persistence—an interaction termed “cross-respiration.”
Published Version: doi:10.1128/mBio.01249-16
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33867377
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters