dc.contributor.author | Quirk, Michael C. | |
dc.contributor.author | Sosulski, Dara L. | |
dc.contributor.author | Feierstein, Claudia E. | |
dc.contributor.author | Uchida, Naoshige | |
dc.contributor.author | Mainen, Zachary F. | |
dc.date.accessioned | 2017-09-19T15:54:50Z | |
dc.date.issued | 2009 | |
dc.identifier | Quick submit: 2013-07-09T10:48:06-04:00 | |
dc.identifier.citation | Quirk, Michael C., Dara L. Sosulski, Claudia E. Feierstein, Naoshige Uchida, and Zachary F. Mainen. 2009. A defined network of fast-spiking interneurons in orbitofrontal cortex: Responses to behavioral contingencies and ketamine administration. Frontiers in Systems Neuroscience 3. doi:10.3389/neuro.06.013.2009. | en_US |
dc.identifier.issn | 1662-5137 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:33907952 | |
dc.description.abstract | Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC–FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states. | en_US |
dc.description.sponsorship | Molecular and Cellular Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Frontiers Media SA | en_US |
dc.relation.isversionof | doi:10.3389/neuro.06.013.2009 | en_US |
dash.license | LAA | |
dc.subject | schizophrenia | en_US |
dc.subject | depression | en_US |
dc.subject | fast-spiking interneuron | en_US |
dc.subject | motivation | en_US |
dc.subject | parvalbumin | en_US |
dc.subject | psychosis | en_US |
dc.title | A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration | en_US |
dc.type | Journal Article | en_US |
dc.date.updated | 2013-07-09T14:48:33Z | |
dc.description.version | Version of Record | en_US |
dc.rights.holder | Michael C Quirk, Dara L Sosulski, Claudia E Feierstein, Naoshige Uchida, Zachary F Mainen | |
dc.relation.journal | Frontiers in Systems Neuroscience | en_US |
dash.depositing.author | Uchida, Naoshige | |
dc.date.available | 2017-09-19T15:54:50Z | |
dc.identifier.doi | 10.3389/neuro.06.013.2009 | * |
dash.contributor.affiliated | Uchida, Naoshige | |