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dc.contributor.authorAgar, Nathalie Marie Yvonne Rachel
dc.contributor.authorGolby, Alexandra Jacqueline
dc.contributor.authorLigon, Keith Lloyd
dc.contributor.authorNorton, Isaiah Hakim
dc.contributor.authorMohan, Vandana
dc.contributor.authorWiseman, Justin M
dc.contributor.authorTannenbaum, Allen
dc.contributor.authorJolesz, Ferenc A.
dc.date.accessioned2017-10-10T14:31:57Z
dc.date.issued2011
dc.identifierQuick submit: 2013-11-15T10:34:47-05:00
dc.identifier.citationAgar, Nathalie Y.R., Alexandra J. Golby, Keith L. Ligon, Isaiah Norton, Vandana Mohan, Justin M. Wiseman, Allen Tannenbaum, and Ferenc A. Jolesz. 2011. “Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery.” Neurosurgery 68 (2) (February): 280–290. doi:10.1227/neu.0b013e3181ff9cbb.en_US
dc.identifier.issn0148-396Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34165596
dc.description.abstractBACKGROUND: Surgery remains the first and most important treatment modality for the majority of solid tumors. Across a range of brain tumor types and grades, postoperative residual tumor has a great impact on prognosis. The principal challenge and objective of neurosurgical intervention is therefore to maximize tumor resection while minimizing the potential for neurological deficit by preserving critical tissue. OBJECTIVE: To introduce the integration of desorption electrospray ionization mass spectrometry into surgery for in vivo molecular tissue characterization and intraoperative definition of tumor boundaries without systemic injection of contrast agents. METHODS: Using a frameless stereotactic sampling approach and by integrating a 3-dimensional navigation system with an ultrasonic surgical probe, we obtained image-registered surgical specimens. The samples were analyzed with ambient desorption/ionization mass spectrometry and validated against standard histopathology. This new approach will enable neurosurgeons to detect tumor infiltration of the normal brain intraoperatively with mass spectrometry and to obtain spatially resolved molecular tissue characterization without any exogenous agent and with high sensitivity and specificity. RESULTS: Proof of concept is presented in using mass spectrometry intraoperatively for real-time measurement of molecular structure and using that tissue characterization method to detect tumor boundaries. Multiple sampling sites within the tumor mass were defined for a patient with a recurrent left frontal oligodendroglioma, World Health Organization grade II with chromosome 1p/19q codeletion, and mass spectrometry data indicated a correlation between lipid constitution and tumor cell prevalence. CONCLUSION: The mass spectrometry measurements reflect a complex molecular structure and are integrated with frameless stereotaxy and imaging, providing 3-dimensional molecular imaging without systemic injection of any agents, which can be implemented for surgical margins delineation of any organ and with a rapidity that allows real-time analysis.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.isversionofdoi:10.1227/neu.0b013e3181ff9cbben_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678259/en_US
dash.licenseLAA
dc.subjectBrain neoplasms; Histopathology; Mass spectrometry; Neuronavigation; Neurosurgery; Stereotactic techniquesen_US
dc.titleDevelopment of Stereotactic Mass Spectrometry for Brain Tumor Surgeryen_US
dc.typeJournal Articleen_US
dc.date.updated2013-11-15T15:35:58Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderAgar NY, Golby AJ, Ligon KL, Norton I, Mohan V, Wiseman JM, Tannenbaum A, Jolesz FA.
dc.relation.journalNeurosurgeryen_US
dash.depositing.authorGolby, Alexandra Jacqueline
dc.date.available2017-10-10T14:31:57Z
dc.identifier.doi10.1227/neu.0b013e3181ff9cbb*
workflow.legacycommentsaa.no Golby. Golby emailed for aa 04-25-2017 MMen_US
dash.contributor.affiliatedGolby, Alexandra
dash.contributor.affiliatedNorton, Isaiah Hakim
dash.contributor.affiliatedJolesz, Ferenc
dash.contributor.affiliatedAgar, Nathalie
dash.contributor.affiliatedLigon, Keith


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