A prospective study of oral contraceptive use and colorectal adenomas

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A prospective study of oral contraceptive use and colorectal adenomas

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Title: A prospective study of oral contraceptive use and colorectal adenomas
Author: Charlton, Brittany Michelle; Giovannucci, Edward L.; Fuchs, Charles Stewart; Chan, Andrew Tan; Lee, Jung; Cao, Yin; Missmer, Stacey Ann; Rosner, Bernard Alfred; Hankinson, Susan Elizabeth; Willett, Walter C.; Wu, Kana; Michels, Karin B.

Note: Order does not necessarily reflect citation order of authors.

Citation: Charlton, Brittany M., Edward Giovannucci, Charles S. Fuchs, Andrew T. Chan, Jung Eun Lee, Yin Cao, Stacey A. Missmer, et al. 2016. “A Prospective Study of Oral Contraceptive Use and Colorectal Adenomas.” Cancer Causes & Control 27 (6) (April 28): 749–757. doi:10.1007/s10552-016-0752-3.
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Abstract: Purpose—The influence of reproductive factors on colorectal cancer, including oral contraceptive (OC) use, has been examined, but less research is available on OC use and adenomas.

Methods—Participants of the Nurses' Health Study who had a lower bowel endoscopy between 1986 (when endoscopies were first assessed) through 2008 where included in this study. Multivariable logistic regression models for clustered data were used to estimate odds ratios and 95% confidence intervals [OR (95% CIs)].

Results—Among 73,058 participants, 51% (N=37,382) reported ever using OCs. Ever OC use was associated with a slight increase of non-advanced adenomas [OR=1.11 95% CI (1.02, 1.21)] but not with any other endpoints. Duration of OC use was not associated with adenomas, but longer times since last OC use were associated with increased odds of adenomas [e.g., compared to never use, 15+ years since last use: OR=1.17 (1.07, 1.27)]. Shorter times since last OC use were inversely associated [e.g., ≤4 years since last use: OR=0.74 (0.65, 0.84)].

Conclusions—We observed a modest borderline increase in risk of colorectal adenomas with any prior OC use. Additionally, more recent OC use may decrease risk while exposure in the distant past may modestly increase risk of adenomas.
Published Version: 10.1007/s10552-016-0752-3
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177026/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34216316
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