# Nuclear spin singlet states as a contrast mechanism for NMR spectroscopy

 Title: Nuclear spin singlet states as a contrast mechanism for NMR spectroscopy Author: Devience, Stephen J; Walsworth, Ronald Lee; Rosen, Matthew Scot Note: Order does not necessarily reflect citation order of authors. Citation: DeVience, Stephen J., Ronald L. Walsworth, and Matthew S. Rosen. 2013. “Nuclear Spin Singlet States as a Contrast Mechanism for NMR Spectroscopy.” NMR in Biomedicine 26 (10) (April 18): 1204–1212. doi:10.1002/nbm.2936. Access Status: Full text of the requested work is not available in DASH at this time (“dark deposit”). For more information on dark deposits, see our FAQ. Full Text & Related Files: Nuclear Spin Si ... m for NMR Spectroscopy.pdf (993.2Kb; PDF) Abstract: Nuclear magnetic resonance (NMR) spectra of complex chemical mixtures often contain unresolved or hidden spectral components, especially when strong background signals overlap weaker peaks. In this article we demonstrate a quantum filter utilizing nuclear spin singlet states, which allows undesired NMR spectral background to be removed and target spectral peaks to be uncovered. The quantum filter is implemented by creating a nuclear spin singlet state with spin quantum numbers j = 0, m$$_z$$ = 0 in a target molecule, applying a continuous RF field to both preserve the singlet state and saturate the magnetization of undesired molecules and then mapping the target molecule singlet state back into an NMR observable state so that its spectrum can be read out unambiguously. The preparation of the target singlet state can be carefully controlled with pulse sequence parameters, so that spectral contrast can be achieved between molecules with very similar structures. We name this NMR contrast mechanism ‘Suppression of Undesired Chemicals using Contrast-Enhancing Singlet States’ (SUCCESS) and we demonstrate it in vitro for three target molecules relevant to neuroscience: aspartate, threonine and glutamine. Published Version: doi:10.1002/nbm.2936 Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34222822 Downloads of this work: