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dc.contributor.authorAbzhanov, Arkhat
dc.contributor.authorRodda, S. J.
dc.contributor.authorMcMahon, A. P.
dc.contributor.authorTabin, Clifford James
dc.date.accessioned2017-10-16T19:32:40Z
dc.date.issued2007
dc.identifier.citationAbzhanov, A., S. J. Rodda, A. P. McMahon, and C. J. Tabin. 2007. “Regulation of Skeletogenic Differentiation in Cranial Dermal Bone.” Development 134 (17) (August 1): 3133–3144. doi:10.1242/dev.002709.en_US
dc.identifier.issn0950-1991en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34222830
dc.description.abstractAlthough endochondral ossification of the limb and axial skeleton is relatively well-understood, the development of dermal (intramembranous) bone featured by many craniofacial skeletal elements is not nearly as well-characterized. We analyzed the expression domains of a number of markers that have previously been associated with endochondral skeleton development to define the cellular transitions involved in the dermal ossification process in both chick and mouse. This led to the recognition of a series of distinct steps in the dermal differentiation pathways, including a unique cell type characterized by the expression of both osteogenic and chondrogenic markers. Several signaling molecules previously implicated in endochondrial development were found to be expressed during specific stages of dermal bone formation. Three of these were studied functionally using retroviral misexpression. We found that activity of bone morphogenic proteins (BMPs) is required for neural crest-derived mesenchyme to commit to the osteogenic pathway and that both Indian hedgehog (IHH) and parathyroid hormone-related protein (PTHrP, PTHLH) negatively regulate the transition from preosteoblastic progenitors to osteoblasts. These results provide a framework for understanding dermal bone development with an aim of bringing it closer to the molecular and cellular resolution available for the endochondral bone development.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherThe Company of Biologistsen_US
dc.relation.isversionofdoi:10.1242/dev.002709en_US
dash.licenseLAA
dc.subjectDermal bone, intramembranous ossification, cranial development, mouse, chicken_US
dc.titleRegulation of skeletogenic differentiation in cranial dermal boneen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDevelopmenten_US
dash.depositing.authorAbzhanov, Arkhat
dc.date.available2017-10-16T19:32:40Z
dc.identifier.doi10.1242/dev.002709*
dash.contributor.affiliatedTabin, Clifford
dash.contributor.affiliatedAbzhanov, Arkhat


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