The Rectal Tonsil: A Reactive Lymphoid Proliferation That May Mimic Lymphoma
View/ Open
Lauwers_RectalTonsil.pdf (449.8Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Published Version
https://doi.org/10.1097/PAS.0b013e318162c3ecMetadata
Show full item recordCitation
Farris, Alton B., Gregory Y. Lauwers, Judith A. Ferry, and Lawrence R. Zukerberg. 2008. “The Rectal Tonsil: A Reactive Lymphoid Proliferation That May Mimic Lymphoma.” The American Journal of Surgical Pathology 32 (7) (July): 1075–1079. doi:10.1097/pas.0b013e318162c3ec.Abstract
The rectal tonsil (RT), a localized reactive proliferation of lymphoid tissue occurring in the rectum, can cause diagnostic difficulty; and awareness of this entity can prevent a misdiagnosis of lymphoma. A clinicopathologic analysis of 11 cases of RT was performed to determine the features that can aid in the recognition of this entity. The patients (6 males and 5 females) were middle-aged adults, except for 1 case affecting a young boy (age range, 1 to 62 y; mean, 49 y). All presented with either rectal bleeding or abdominal pain, or had the lesion found on routine screening. Endoscopic descriptions, available in all cases, reported a raised, polypoid lesion in 8 cases, a nodule in 2 cases, and a "mass" in 1 case. Histologically, all cases were composed of a lymphoid proliferation involving the lamina propria or submucosa. Lymphoid follicles could be identified in all cases, although some were difficult to appreciate without immunostains for follicular dendritic cells. Five cases showed overlying cryptitis and mild architectural distortion, but no cases showed crypt obliteration or crypt abscesses. Intraepithelial lymphocytes were present in 9 cases, and 5 cases showed nondestructive lymphoepithelial lesions. During a mean follow-up of 5.8 years, none showed a recurrence or developed lymphoma. In conclusion, RT, with its distinctive features, is an important entity to recognize. Familiarity with the range of histologic features characteristic of the RT is critical in avoiding misinterpretation as lymphoma.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:34268568
Collections
- HMS Scholarly Articles [17875]
Contact administrator regarding this item (to report mistakes or request changes)