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dc.contributor.authorLeslie, Daniel
dc.contributor.authorWaterhouse, Anna
dc.contributor.authorBerthet, Julia B
dc.contributor.authorValentin, Thomas M
dc.contributor.authorWatters, Alexander
dc.contributor.authorJain, Abhishek
dc.contributor.authorKim, Philseok
dc.contributor.authorHatton, Benjamin D
dc.contributor.authorNedder, Arthur
dc.contributor.authorDonovan, Kathryn
dc.contributor.authorSuper, Elana H
dc.contributor.authorHowell, Caitlin
dc.contributor.authorJohnson, Christopher P
dc.contributor.authorVu, Thy L
dc.contributor.authorBolgen, Dana
dc.contributor.authorRifai, Sami
dc.contributor.authorHansen, Anne Rosenfeld
dc.contributor.authorAizenberg, Michael
dc.contributor.authorSuper, Michael
dc.contributor.authorAizenberg, Joanna
dc.contributor.authorIngber, Donald Elliot
dc.date.accessioned2017-10-26T17:35:22Z
dc.date.issued2014
dc.identifier.citationLeslie, Daniel C, Anna Waterhouse, Julia B Berthet, Thomas M Valentin, Alexander L Watters, Abhishek Jain, Philseok Kim, et al. 2014. “A Bioinspired Omniphobic Surface Coating on Medical Devices Prevents Thrombosis and Biofouling.” Nature Biotechnology 32 (11) (October 12): 1134–1140. doi:10.1038/nbt.3020.en_US
dc.identifier.issn1087-0156en_US
dc.identifier.issn1546-1696en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34298865
dc.description.abstractThrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We describe a bioinspired coating that repels blood from virtually any material by covalently tethering a molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the substrate surface, mimicking the liquid layer certain plants use to prevent adhesion. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation, and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in living pigs, remain patent for at least 8 hours without anticoagulation. This coating technology offers the potential to significantly reduce anticoagulation in patients while preventing thrombotic occlusion and biofouling of medical devices.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/nbt.3020en_US
dash.licenseLAA
dc.titleA bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofoulingen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNat Biotechnolen_US
dash.depositing.authorIngber, Donald Elliot
dash.waiver2014-07-16
dc.date.available2017-10-26T17:35:22Z
dash.affiliation.otherHarvard Medical Schoolen_US
dc.identifier.doi10.1038/nbt.3020*
workflow.legacycommentsArticle From Waiver Tableen_US
dash.authorsorderedfalse
dash.contributor.affiliatedWatters, Alexander
dash.contributor.affiliatedJain, Abhishek
dash.contributor.affiliatedHansen, Anne
dash.contributor.affiliatedBolgen, Dana
dash.contributor.affiliatedHowell, Caitlin
dash.contributor.affiliatedWaterhouse, Anna
dash.contributor.affiliatedLeslie, Daniel
dash.contributor.affiliatedSuper, Michael
dash.contributor.affiliatedKim, Philseok
dash.contributor.affiliatedAizenberg, Michael
dash.contributor.affiliatedIngber, Donald


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