A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair

DSpace/Manakin Repository

A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair

Citable link to this page

 

 
Title: A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair
Author: Pakotiprapha, Danaya; Liu, Yi; Verdine, Gregory L.; Jeruzalmi, David

Note: Order does not necessarily reflect citation order of authors.

Citation: Pakotiprapha, Danaya, Yi Liu, Gregory L. Verdine, and David Jeruzalmi. 2009. “A Structural Model for the Damage-Sensing Complex in Bacterial Nucleotide Excision Repair.” Journal of Biological Chemistry 284 (19) (March 13): 12837–12844. doi:10.1074/jbc.m900571200.
Full Text & Related Files:
Abstract: Nucleotide excision repair is distinguished from other DNA repair pathways by its ability to process a wide range of structurally unrelated DNA lesions. In bacteria, damage recognition is achieved by the UvrA·UvrB ensemble. Here, we report the structure of the complex between the interaction domains of UvrA and UvrB. These domains are necessary and sufficient for full-length UvrA and UvrB to associate and thereby form the DNA damage-sensing complex of bacterial nucleotide excision repair. The crystal structure and accompanying biochemical analyses suggest a model for the complete damage-sensing complex.
Published Version: doi:10.1074/jbc.m900571200
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676014/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34305981
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters