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dc.contributor.authorMcCracken, Michael K.en_US
dc.contributor.authorGromowski, Gregory D.en_US
dc.contributor.authorFriberg, Heather L.en_US
dc.contributor.authorLin, Xiaoxuen_US
dc.contributor.authorAbbink, Peteren_US
dc.contributor.authorDe La Barrera, Rafaelen_US
dc.contributor.authorEckles, Kenneth H.en_US
dc.contributor.authorGarver, Lindsey S.en_US
dc.contributor.authorBoyd, Michaelen_US
dc.contributor.authorJetton, Daviden_US
dc.contributor.authorBarouch, Dan H.en_US
dc.contributor.authorWise, Matthew C.en_US
dc.contributor.authorLewis, Bridget S.en_US
dc.contributor.authorCurrier, Jeffrey R.en_US
dc.contributor.authorModjarrad, Kayvonen_US
dc.contributor.authorMilazzo, Marken_US
dc.contributor.authorLiu, Michelleen_US
dc.contributor.authorMullins, Anna B.en_US
dc.contributor.authorPutnak, J. Roberten_US
dc.contributor.authorMichael, Nelson L.en_US
dc.contributor.authorJarman, Richard G.en_US
dc.contributor.authorThomas, Stephen J.en_US
dc.date.accessioned2017-11-21T20:40:41Z
dc.date.issued2017en_US
dc.identifier.citationMcCracken, M. K., G. D. Gromowski, H. L. Friberg, X. Lin, P. Abbink, R. De La Barrera, K. H. Eckles, et al. 2017. “Impact of prior flavivirus immunity on Zika virus infection in rhesus macaques.” PLoS Pathogens 13 (8): e1006487. doi:10.1371/journal.ppat.1006487. http://dx.doi.org/10.1371/journal.ppat.1006487.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34375060
dc.description.abstractStudies have demonstrated cross-reactivity of anti-dengue virus (DENV) antibodies in human sera against Zika virus (ZIKV), promoting increased ZIKV infection in vitro. However, the correlation between in vitro and in vivo findings is not well characterized. Thus, we evaluated the impact of heterotypic flavivirus immunity on ZIKV titers in biofluids of rhesus macaques. Animals previously infected (≥420 days) with DENV2, DENV4, or yellow fever virus were compared to flavivirus-naïve animals following infection with a Brazilian ZIKV strain. Sera from DENV-immune macaques demonstrated cross-reactivity with ZIKV by antibody-binding and neutralization assays prior to ZIKV infection, and promoted increased ZIKV infection in cell culture assays. Despite these findings, no significant differences between flavivirus-naïve and immune animals were observed in viral titers, neutralizing antibody levels, or immune cell kinetics following ZIKV infection. These results indicate that prior infection with heterologous flaviviruses neither conferred protection nor increased observed ZIKV titers in this non-human primate ZIKV infection model.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.ppat.1006487en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542404/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and life sciencesen
dc.subjectOrganismsen
dc.subjectVirusesen
dc.subjectRNA virusesen
dc.subjectFlavivirusesen
dc.subjectZika Virusen
dc.subjectBiology and Life Sciencesen
dc.subjectMicrobiologyen
dc.subjectMedical Microbiologyen
dc.subjectMicrobial Pathogensen
dc.subjectViral Pathogensen
dc.subjectMedicine and Health Sciencesen
dc.subjectPathology and Laboratory Medicineen
dc.subjectPathogensen
dc.subjectPhysiologyen
dc.subjectImmune Physiologyen
dc.subjectAntibodiesen
dc.subjectImmunologyen
dc.subjectImmune System Proteinsen
dc.subjectBiochemistryen
dc.subjectProteinsen
dc.subjectImmunologic Techniquesen
dc.subjectImmunoassaysen
dc.subjectEnzyme-Linked Immunoassaysen
dc.subjectAnimalsen
dc.subjectVertebratesen
dc.subjectAmniotesen
dc.subjectMammalsen
dc.subjectPrimatesen
dc.subjectMonkeysen
dc.subjectOld World monkeysen
dc.subjectMacaqueen
dc.subjectMolecular Biologyen
dc.subjectMolecular Biology Techniquesen
dc.subjectCloningen
dc.subjectAnatomyen
dc.subjectBody Fluidsen
dc.subjectBlooden
dc.subjectExperimental Organism Systemsen
dc.subjectAnimal Modelsen
dc.subjectRhesus Monkeysen
dc.subjectInfectious Diseasesen
dc.subjectViral Diseasesen
dc.subjectViremiaen
dc.titleImpact of prior flavivirus immunity on Zika virus infection in rhesus macaquesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS Pathogensen
dash.depositing.authorBarouch, Dan H.en_US
dc.date.available2017-11-21T20:40:41Z
dc.identifier.doi10.1371/journal.ppat.1006487*
dash.authorsorderedfalse
dash.contributor.affiliatedBarouch, Dan


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