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dc.contributor.authorAmadi, Beatriceen_US
dc.contributor.authorBesa, Ellenen_US
dc.contributor.authorZyambo, Kanekwaen_US
dc.contributor.authorKaonga, Patricken_US
dc.contributor.authorLouis-Auguste, Johnen_US
dc.contributor.authorChandwe, Kantaen_US
dc.contributor.authorTarr, Phillip I.en_US
dc.contributor.authorDenno, Donna M.en_US
dc.contributor.authorNataro, James P.en_US
dc.contributor.authorFaubion, Williamen_US
dc.contributor.authorSailer, Anneen_US
dc.contributor.authorYeruva, Sunilen_US
dc.contributor.authorBrantner, Triciaen_US
dc.contributor.authorMurray, Josephen_US
dc.contributor.authorPrendergast, Andrew J.en_US
dc.contributor.authorTurner, Jerrold R.en_US
dc.contributor.authorKelly, Paulen_US
dc.date.accessioned2017-11-21T20:41:27Z
dc.date.issued2017en_US
dc.identifier.citationAmadi, B., E. Besa, K. Zyambo, P. Kaonga, J. Louis-Auguste, K. Chandwe, P. I. Tarr, et al. 2017. “Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia.” EBioMedicine 22 (1): 191-199. doi:10.1016/j.ebiom.2017.07.017. http://dx.doi.org/10.1016/j.ebiom.2017.07.017.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34375095
dc.description.abstractIntestinal damage in malnutrition constitutes a threat to the survival of many thousands of children globally. We studied children in Lusaka, Zambia, with severe acute malnutrition (SAM) and persistent diarrhea using endoscopy, biopsy and analysis of markers and protective proteins in blood and intestinal secretions. We carried out parallel investigations in apparently healthy adults, and analyzed biomarkers only in apparently healthy children. Villus height and crypt depth did not differ in children with SAM and adult controls, but epithelial surface was reduced in children with SAM (median 445, interquartile range (IQR) 388, 562 μm per 100 μm muscularis mucosae) compared to adults (578, IQR 465,709; P = 0.004). Histological lesions and disruptions of claudin-4 and E-cadherin were most pronounced in children with SAM. Circulating lipopolysaccharide, a marker of bacterial translocation, was higher in malnourished children (251, IQR 110,460 EU/ml) than in healthy children (51, IQR 0,111; P = 0.0001). Other translocation markers showed similar patterns. Anti-Deamidated Gliadin Peptide IgG concentrations, although within the normal range, were higher in children with SAM (median 2.7 U/ml, IQR 1.5–8.6) than in adults (1.6, 1.4–2.1; P = 0.005), and were inversely correlated with villus height (ρ = − 0.79, n = 13, P = 0.001). Malnutrition enteropathy is associated with intestinal barrier failure and immune dysregulation.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofdoi:10.1016/j.ebiom.2017.07.017en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552244/pdf/en
dash.licenseLAAen_US
dc.subjectEnteropathyen
dc.subjectEnvironmental enteric dysfunctionen
dc.subjectHIVen
dc.subjectMalnutritionen
dc.subjectGlucagon-like peptide 2en
dc.subjectMicrobial translocationen
dc.subjectAutoantibodiesen
dc.subjectTissue transglutaminase serology, deamidated gliadin peptide serologyen
dc.titleImpaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambiaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEBioMedicineen
dash.depositing.authorTurner, Jerrold R.en_US
dc.date.available2017-11-21T20:41:27Z
dc.identifier.doi10.1016/j.ebiom.2017.07.017*
dash.authorsorderedfalse
dash.contributor.affiliatedTurner, Jerrold


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