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dc.contributor.authorKim, Hwijinen_US
dc.date.accessioned2017-11-21T20:42:04Z
dc.date.issued2017en_US
dc.identifier.citationKim, Hwijin. 2017. “The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages.” Scientific Reports 7 (1): 7591. doi:10.1038/s41598-017-07381-8. http://dx.doi.org/10.1038/s41598-017-07381-8.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34375124
dc.description.abstractMacrophages play pivotal roles in the progression and regression of atherosclerosis. Accumulating evidence suggests that macrophage polarization into an anti-inflammatory M2 state is a key characteristic of atherosclerotic plaques undergoing regression. However, the molecular mechanisms underlying this potential association of the M2 polarization with atherosclerosis regression remain poorly understood. Further, human genetic factors that facilitate these anti-atherogenic processes remain largely unknown. We report that the transcription factor MafB plays pivotal roles in promoting macrophage M2 polarization. Further, MafB promotes cholesterol efflux from macrophage foam cells by directly up-regulating its key cellular mediators. Notably, MafB expression is significantly up-regulated in response to various metabolic and immunological stimuli that promote macrophage M2 polarization or cholesterol efflux, and thereby MafB mediates their beneficial effects, in both liver x receptor (LXR)-dependent and independent manners. In contrast, MafB is strongly down-regulated upon elevated pro-inflammatory signaling or by pro-inflammatory and pro-atherogenic microRNAs, miR-155 and miR-33. Using an integrative systems biology approach, we also revealed that M2 polarization and cholesterol efflux do not necessarily represent inter-dependent events, but MafB is broadly involved in both the processes. These findings highlight physiological protective roles that MafB may play against atherosclerosis progression.en
dc.language.isoen_USen
dc.publisherNature Publishing Group UKen
dc.relation.isversionofdoi:10.1038/s41598-017-07381-8en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548719/pdf/en
dash.licenseLAAen_US
dc.titleThe transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophagesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dc.date.available2017-11-21T20:42:04Z
dc.identifier.doi10.1038/s41598-017-07381-8*


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