Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease

DSpace/Manakin Repository

Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease

Citable link to this page

 

 
Title: Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease
Author: Gamberger, Dragan; Lavrač, Nada; Srivatsa, Shantanu; Tanzi, Rudolph E.; Doraiswamy, P. Murali

Note: Order does not necessarily reflect citation order of authors.

Citation: Gamberger, Dragan, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, and P. Murali Doraiswamy. 2017. “Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s disease.” Scientific Reports 7 (1): 6763. doi:10.1038/s41598-017-06624-y. http://dx.doi.org/10.1038/s41598-017-06624-y.
Full Text & Related Files:
Abstract: The heterogeneity of Alzheimer’s disease contributes to the high failure rate of prior clinical trials. We analyzed 5-year longitudinal outcomes and biomarker data from 562 subjects with mild cognitive impairment (MCI) from two national studies (ADNI) using a novel multilayer clustering algorithm. The algorithm identified homogenous clusters of MCI subjects with markedly different prognostic cognitive trajectories. A cluster of 240 rapid decliners had 2-fold greater atrophy and progressed to dementia at almost 5 times the rate of a cluster of 184 slow decliners. A classifier for identifying rapid decliners in one study showed high sensitivity and specificity in the second study. Characterizing subgroups of at risk subjects, with diverse prognostic outcomes, may provide novel mechanistic insights and facilitate clinical trials of drugs to delay the onset of AD.
Published Version: doi:10.1038/s41598-017-06624-y
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533731/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34375133
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters