Germline factor DDX4 functions in blood‐derived cancer cell phenotypes

DSpace/Manakin Repository

Germline factor DDX4 functions in blood‐derived cancer cell phenotypes

Citable link to this page


Title: Germline factor DDX4 functions in blood‐derived cancer cell phenotypes
Author: Schudrowitz, Natalie; Takagi, Satoshi; Wessel, Gary M.; Yajima, Mamiko

Note: Order does not necessarily reflect citation order of authors.

Citation: Schudrowitz, Natalie, Satoshi Takagi, Gary M. Wessel, and Mamiko Yajima. 2017. “Germline factor DDX4 functions in blood‐derived cancer cell phenotypes.” Cancer Science 108 (8): 1612-1619. doi:10.1111/cas.13299.
Full Text & Related Files:
Abstract: DDX4 (the human ortholog of Drosophila Vasa) is an RNA helicase and is present in the germ lines of all metazoans tested. It was historically thought to be expressed specifically in germline, but with additional organisms studied, it is now clear that in some animals DDX4/Vasa functions outside of the germline, in a variety of somatic cells in the embryo and in the adult. In this report, we document that DDX4 is widely expressed in soma‐derived cancer cell lines, including myeloma (IM‐9) and leukemia (THP‐1) cells. In these cells, the DDX4 protein localized to the mitotic spindle, consistent with findings in other somatic cell functions, and its knockout in IM‐9 cells compromised cell proliferation and migration activities, and downregulated several cell cycle/oncogene factors such as CyclinB and the transcription factor E2F1. These results suggest that DDX4 positively regulates cell cycle progression of diverse somatic‐derived blood cancer cells, implying its broad contributions to the cancer cell phenotype and serves as a potential new target for chemotherapy.
Published Version: doi:10.1111/cas.13299
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search