Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis

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Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis

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Title: Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis
Author: Kuramoto, Nobuo; Ohmura, Koichiro; Ikari, Katsunori; Yano, Koichiro; Furu, Moritoshi; Yamakawa, Noriyuki; Hashimoto, Motomu; Ito, Hiromu; Fujii, Takao; Murakami, Kosaku; Nakashima, Ran; Imura, Yoshitaka; Yukawa, Naoichiro; Yoshifuji, Hajime; Taniguchi, Atsuo; Momohara, Shigeki; Yamanaka, Hisashi; Matsuda, Fumihiko; Mimori, Tsuneyo; Terao, Chikashi

Note: Order does not necessarily reflect citation order of authors.

Citation: Kuramoto, N., K. Ohmura, K. Ikari, K. Yano, M. Furu, N. Yamakawa, M. Hashimoto, et al. 2017. “Anti-centromere antibody exhibits specific distribution levels among anti-nuclear antibodies and may characterize a distinct subset in rheumatoid arthritis.” Scientific Reports 7 (1): 6911. doi:10.1038/s41598-017-07137-4. http://dx.doi.org/10.1038/s41598-017-07137-4.
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Abstract: Anti-centromere antibody (ACA) is one of the classical anti-nuclear antibody (ANA) staining patterns. However, characteristics of ACA in comparison with the other ANA patterns and clinical features of ACA-positive subjects have not been elucidated. Here, we examined all ANA patterns by indirect immunofluorescence for 859 rheumatoid arthritis (RA) patients. Together with the ANA data of 9,575 healthy volunteers, we compared distributions of the ANA levels. ACA was the only ANA that demonstrated a definite bimodal distribution of levels. ACA showed significantly higher levels than the other ANA staining patterns in both RA and healthy population (p < 0.0001). ACA-positivity was associated with old age and was observed more in females. We further recruited another cohort of 3,353 RA patients and confirmed the findings. ACA was also associated with Raynaud’s phenomenon (p = 6.8 × 10−11) in RA. As a conclusion, ACA displays a specific ANA staining pattern with a bimodal distribution, and ACA-positive RA may constitute a distinct subset with specific clinical features.
Published Version: doi:10.1038/s41598-017-07137-4
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537247/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34375154
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