The CREST-E study of creatine for Huntington disease: A randomized controlled trial

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The CREST-E study of creatine for Huntington disease: A randomized controlled trial

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Title: The CREST-E study of creatine for Huntington disease: A randomized controlled trial
Author: Hersch, Steven M.; Schifitto, Giovanni; Oakes, David; Bredlau, Amy-Lee; Meyers, Catherine M.; Nahin, Richard; Rosas, Herminia Diana

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Citation: Hersch, Steven M., Giovanni Schifitto, David Oakes, Amy-Lee Bredlau, Catherine M. Meyers, Richard Nahin, and Herminia Diana Rosas. 2017. “The CREST-E study of creatine for Huntington disease: A randomized controlled trial.” Neurology 89 (6): 594-601. doi:10.1212/WNL.0000000000004209. http://dx.doi.org/10.1212/WNL.0000000000004209.
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Abstract: Objective: To investigate whether creatine administration could slow progressive functional decline in adults with early symptoms of Huntington disease. Methods: We conducted a multicenter, randomized, double-blind, placebo-controlled study of up to 40 g daily of creatine monohydrate in participants with stage I and II HD treated for up to 48 months. The primary outcome measure was the rate of change in total functional capacity (TFC) between baseline and end of follow-up. Secondary outcome measures included changes in additional clinical scores, tolerability, and quality of life. Safety was assessed by adverse events and laboratory studies. Results: At 46 sites in North America, Australia, and New Zealand, 553 participants were randomized to creatine (275) or placebo (278). The trial was designed to enroll 650 patients, but was halted for futility after the first interim analysis. The estimated rates of decline in the primary outcome measure (TFC) were 0.82 points per year for participants on creatine, 0.70 points per year for participants on placebo, favoring placebo (nominal 95% confidence limits −0.11 to 0.35). Adverse events, mainly gastrointestinal, were significantly more common in participants on creatine. Serious adverse events, including deaths, were more frequent in the placebo group. Subgroup analysis suggested that men and women may respond differently to creatine treatment. Conclusions: Our data do not support the use of creatine treatment for delaying functional decline in early manifest HD. Clinicaltrials.gov identifier: NCT00712426. Classification of evidence: This study provides Class II evidence that for patients with early symptomatic HD, creatine monohydrate is not beneficial for slowing functional decline.
Published Version: doi:10.1212/WNL.0000000000004209
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562960/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34375176
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