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dc.contributor.authorBrittain, Evan L.en_US
dc.contributor.authorNwabuo, Chikeen_US
dc.contributor.authorXu, Mengen_US
dc.contributor.authorGupta, Deepak K.en_US
dc.contributor.authorHemnes, Anna R.en_US
dc.contributor.authorMoreira, Henrique T.en_US
dc.contributor.authorDe Vasconcellos, Henrique Doriaen_US
dc.contributor.authorTerry, James G.en_US
dc.contributor.authorCarr, Jeffrey J.en_US
dc.contributor.authorLima, Joao A. C.en_US
dc.date.accessioned2017-11-21T20:44:08Z
dc.date.issued2017en_US
dc.identifier.citationBrittain, Evan L., Chike Nwabuo, Meng Xu, Deepak K. Gupta, Anna R. Hemnes, Henrique T. Moreira, Henrique Doria De Vasconcellos, James G. Terry, Jeffrey J. Carr, and Joao A. C. Lima. 2017. “Echocardiographic Pulmonary Artery Systolic Pressure in the Coronary Artery Risk Development in Young Adults (CARDIA) Study: Associations With Race and Metabolic Dysregulation.” Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 6 (4): e005111. doi:10.1161/JAHA.116.005111. http://dx.doi.org/10.1161/JAHA.116.005111.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34375223
dc.description.abstractBackground: The determinants of pulmonary artery systolic pressure (PASP) are not fully understood. It is unknown whether racial differences in PASP exist or if other population characteristics are associated with pulmonary pressure in humans. We examined echocardiographically estimated PASP in the Coronary Artery Risk Development in Young Adults (CARDIA) study, a middle‐aged, biracial community‐based cohort. Methods and Results: At the CARDIA year‐25 examination, 3469 participants underwent echocardiography, including measurement of tricuspid regurgitant jet velocity to estimate PASP. Clinical features, laboratory values, pulmonary function tests, and measurement of adipose depot volume were analyzed for association with PASP. PASP was estimated in 1311 individuals (61% female, 51% white). Older age, higher blood pressure, and higher body mass index were associated with higher PASP. Black race was associated with higher PASP after adjustment for demographics and left and right ventricular function (β 0.94, 95% CI 0.24‐1.64; P=0.009), but this association was no longer significant after further adjustment for lung volume (β 0.42, 95% CI −0.68 to 0.96; P=0.74). Insulin resistance, inflammation (C‐reactive protein and interleukin‐6), and visceral adipose volume were independently associated with higher PASP after adjustment for relevant covariates. PASP rose with worsening diastolic function (ratio of early transmitral Doppler velocity to average mitral annular tissue Doppler velocity [E/e′] and left atrial volume index). Conclusions: In a large biracial cohort of middle‐aged adults, we identified associations among black race, insulin resistance, and diastolic dysfunction with higher echocardiographically estimated PASP. Further studies are needed to examine racial differences in PASP and whether insulin resistance directly contributes to pulmonary vascular disease in humans.en
dc.language.isoen_USen
dc.publisherJohn Wiley and Sons Inc.en
dc.relation.isversionofdoi:10.1161/JAHA.116.005111en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5533013/pdf/en
dash.licenseLAAen_US
dc.subjectadipose tissueen
dc.subjectechocardiographyen
dc.subjectinflammationen
dc.subjectmetabolic syndromeen
dc.subjectpulmonary hypertensionen
dc.subjectMetabolic Syndromeen
dc.subjectPulmonary Hypertensionen
dc.subjectEchocardiographyen
dc.subjectRisk Factorsen
dc.titleEchocardiographic Pulmonary Artery Systolic Pressure in the Coronary Artery Risk Development in Young Adults (CARDIA) Study: Associations With Race and Metabolic Dysregulationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of the American Heart Association: Cardiovascular and Cerebrovascular Diseaseen
dash.depositing.authorNwabuo, Chikeen_US
dc.date.available2017-11-21T20:44:08Z
dc.identifier.doi10.1161/JAHA.116.005111*
dash.contributor.affiliatedNwabuo, Chike


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