Genome-wide identification of autosomal genes with allelic imbalance of chromatin state

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Genome-wide identification of autosomal genes with allelic imbalance of chromatin state

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Title: Genome-wide identification of autosomal genes with allelic imbalance of chromatin state
Author: Savol, Andrej J.; Wang, Peggy I.; Jeon, Yesu; Colognori, David; Yildirim, Eda; Pinter, Stefan F.; Payer, Bernhard; Lee, Jeannie T.; Sadreyev, Ruslan I.

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Citation: Savol, Andrej J., Peggy I. Wang, Yesu Jeon, David Colognori, Eda Yildirim, Stefan F. Pinter, Bernhard Payer, Jeannie T. Lee, and Ruslan I. Sadreyev. 2017. “Genome-wide identification of autosomal genes with allelic imbalance of chromatin state.” PLoS ONE 12 (8): e0182568. doi:10.1371/journal.pone.0182568. http://dx.doi.org/10.1371/journal.pone.0182568.
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Abstract: In mammals, monoallelic gene expression can result from X-chromosome inactivation, genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation of RMAE is not fully understood. Here we analyze allelic imbalance in chromatin state of autosomal genes using ChIP-seq in a clonal cell line. We identify approximately 3.7% of autosomal genes that show significant differences between chromatin states of two alleles. Allelic regulation is represented among several functional gene categories including histones, chromatin modifiers, and multiple early developmental regulators. Most cases of allelic skew are produced by quantitative differences between two allelic chromatic states that belong to the same gross type (active, silent, or bivalent). Combinations of allelic states of different types are possible but less frequent. When different chromatin marks are skewed on the same gene, their skew is coordinated as a result of quantitative relationships between these marks on each individual allele. Finally, combination of allele-specific densities of chromatin marks is a quantitative predictor of allelic skew in gene expression.
Published Version: doi:10.1371/journal.pone.0182568
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552117/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34375285
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