Dectin-1 Activation Controls Maturation of β-1,3-Glucan-containing Phagosomes
Khan, Nida S.
Davids, Peter J.
Stuart, Lynda M.
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CitationMansour, Michael K., Jenny M. Tam, Nida S. Khan, Michael Seward, Peter J. Davids, Sravanthi Puranam, Anna Sokolovska, et al. 2013. “Dectin-1 Activation Controls Maturation of β-1,3-Glucan-Containing Phagosomes.” Journal of Biological Chemistry 288 (22) (April 22): 16043–16054. doi:10.1074/jbc.m113.473223.
AbstractBackground: Dectin-1 is able to recognize and phagocytose the fungal carbohydrate, β-1,3-glucan, but its contribution to phagosomal maturation has not been explored.
Results: Dectin-1-dependent Syk activation promotes phagolysosomal fusion and acidification.
Conclusion: Dectin-1-dependent Syk-activation permits egress of early phagosomes to mature phagolysosomes.
Significance: The surface recognition receptor, Dectin-1 shapes anti-fungal responses by controlling fungal phagosome maturation.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34388154
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