Dectin-1 Activation Controls Maturation of β-1,3-Glucan-containing Phagosomes

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Dectin-1 Activation Controls Maturation of β-1,3-Glucan-containing Phagosomes

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Title: Dectin-1 Activation Controls Maturation of β-1,3-Glucan-containing Phagosomes
Author: Mansour, Michael Karim; Tam, Jenny M.; Khan, Nida S.; Seward, Michael; Davids, Peter J.; Puranam, Sravanthi; Sokolovska, Anna; Sykes, David Brian; Dagher, Zeina; Becker, Christine; Tanne, Antoine; Reedy, Jennifer L; Stuart, Lynda M.; Vyas, Jatin Mahesh

Note: Order does not necessarily reflect citation order of authors.

Citation: Mansour, Michael K., Jenny M. Tam, Nida S. Khan, Michael Seward, Peter J. Davids, Sravanthi Puranam, Anna Sokolovska, et al. 2013. “Dectin-1 Activation Controls Maturation of β-1,3-Glucan-Containing Phagosomes.” Journal of Biological Chemistry 288 (22) (April 22): 16043–16054. doi:10.1074/jbc.m113.473223.
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Abstract: Background: Dectin-1 is able to recognize and phagocytose the fungal carbohydrate, β-1,3-glucan, but its contribution to phagosomal maturation has not been explored.

Results: Dectin-1-dependent Syk activation promotes phagolysosomal fusion and acidification.

Conclusion: Dectin-1-dependent Syk-activation permits egress of early phagosomes to mature phagolysosomes.

Significance: The surface recognition receptor, Dectin-1 shapes anti-fungal responses by controlling fungal phagosome maturation.
Published Version: doi:10.1074/jbc.M113.473223
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668760/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34388154
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