Anaplastic Lymphoma Kinase in Cutaneous Malignancies

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Anaplastic Lymphoma Kinase in Cutaneous Malignancies

Show simple item record Cao, Severine en_US Nambudiri, Vinod E. en_US 2017-12-05T23:51:01Z 2017 en_US
dc.identifier.citation Cao, Severine, and Vinod E. Nambudiri. 2017. “Anaplastic Lymphoma Kinase in Cutaneous Malignancies.” Cancers 9 (9): 123. doi:10.3390/cancers9090123. en
dc.identifier.issn en
dc.description.abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the development of many other hematologic and solid organ malignancies. ALK has now been shown to play a role in the pathogenesis of several cutaneous malignancies, including secondary cutaneous systemic anaplastic large-cell lymphoma (ALCL) and primary cutaneous ALCL, melanoma, spitzoid tumors, epithelioid fibrous histiocytoma, Merkel cell carcinoma, and basal cell carcinoma. The characterization of ALK-positivity in these cutaneous malignancies presents exciting opportunities for utilizing ALK-targeted inhibitors in the treatment of these diseases. en
dc.language.iso en_US en
dc.publisher MDPI en
dc.relation.isversionof doi:10.3390/cancers9090123 en
dc.relation.hasversion en
dash.license LAA en_US
dc.subject anaplastic lymphoma kinase en
dc.subject cutaneous malignancy en
dc.subject anaplastic large cell lymphoma en
dc.subject crizotinib en
dc.title Anaplastic Lymphoma Kinase in Cutaneous Malignancies en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Cancers en Cao, Severine en_US 2017-12-05T23:51:01Z

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