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dc.contributor.authorSima, Corneliuen_US
dc.contributor.authorMontero, Eduardoen_US
dc.contributor.authorNguyen, Danielen_US
dc.contributor.authorFreire, Marceloen_US
dc.contributor.authorNorris, Paulen_US
dc.contributor.authorSerhan, Charles N.en_US
dc.contributor.authorVan Dyke, Thomas E.en_US
dc.date.accessioned2017-12-06T05:49:58Z
dc.date.issued2017en_US
dc.identifier.citationSima, Corneliu, Eduardo Montero, Daniel Nguyen, Marcelo Freire, Paul Norris, Charles N. Serhan, and Thomas E. Van Dyke. 2017. “ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.” Scientific Reports 7 (1): 12848. doi:10.1038/s41598-017-13185-7. http://dx.doi.org/10.1038/s41598-017-13185-7.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34492152
dc.description.abstractNon-resolving inflammation is a central pathologic component of obesity, insulin resistance, type 2 diabetes and associated morbidities. The resultant hyperglycemia is deleterious to the normal function of many organs and its control significantly improves survival and quality of life for patients with diabetes. Macrophages play critical roles in both onset and progression of obesity-associated insulin resistance. Here we show that systemic activation of inflammation resolution prevents from morbid obesity and hyperglycemia under dietary overload conditions. In gain-of-function studies using mice overexpressing the human resolvin E1 receptor (ERV1) in myeloid cells, monocyte phenotypic shifts to increased patrolling-to-inflammatory ratio controlled inflammation, reduced body weight gain and protected from hyperglycemia on high-fat diet. Administration of a natural ERV1 agonist, resolvin E1, recapitulated the pro-resolving actions gained by ERV1 overexpression. This protective metabolic impact is in part explained by systemic activation of resolution programs leading to increased synthesis of specialized pro-resolving mediators.en
dc.language.isoen_USen
dc.publisherNature Publishing Group UKen
dc.relation.isversionofdoi:10.1038/s41598-017-13185-7en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634420/pdf/en
dash.licenseLAAen_US
dc.titleERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intoleranceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalScientific Reportsen
dash.depositing.authorSima, Corneliuen_US
dc.date.available2017-12-06T05:49:58Z
dc.identifier.doi10.1038/s41598-017-13185-7*
dash.contributor.affiliatedVan Dyke, Thomas
dash.contributor.affiliatedSima, Corneliu
dash.contributor.affiliatedNorris, Paul
dash.contributor.affiliatedFreire, Marcelo
dash.contributor.affiliatedSerhan, Charles
dc.identifier.orcid0000-0003-4906-7698


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